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Fig. 6 | Clinical Epigenetics

Fig. 6

From: UHRF1 downregulation promotes T follicular helper cell differentiation by increasing BCL6 expression in SLE

Fig. 6

Model of UHRF1 regulates BCL6 in Tfh cells of SLE patients. In SLE patients, UHRF1 downregulation leads to the decreased DNA methylation and H3K27me3, inducing the activation of BCL6 gene transcription to promote Tfh cell differentiation. The potential mechanism of UHRF1 regulating epigenetic modifications in BCL6 promoter may involve some middle players such as DNMT1, DNMT3A, DNMT3B, EZH2, JMJD6, KDM6A and KDM6B

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Clinical Epigenetics

ISSN: 1868-7083

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