Table 2 Association of overall and progression-free survival with DNAm age
DNAm age | Totala | Overall survival | Progression-free survival | ||
|---|---|---|---|---|---|
HR (95% CI)b | P | HR (95% CI)b | P | ||
Continuous (per 10 years) | 244 | 0.88 (0.78–0.99) | 0.03 | 0.90 (0.80–1.01) | 0.09 |
Categorical (quartile)c | |||||
 First | 60 | 1.00 (ref) | – | 1.00 (ref) | – |
 Second | 60 | 0.85 (0.44–1.62) | 0.61 | 1.07 (0.54–2.09) | 0.85 |
 Third | 61 | 0.60 (0.28–1.26) | 0.17 | 0.84 (0.39–1.81) | 0.65 |
 Fourth | 63 | 0.32 (0.14–0.74) | 0.008 | 0.35 (0.14–0.88) | 0.03 |
Categorical (binary) | |||||
 Decelerated | 145 | 1.00 (ref) | – | 1.00 (ref) | – |
 Accelerated | 99 | 0.59 (0.35–1.00) | 0.05 | 0.53 (0.30–0.93) | 0.03 |