Table 1 Demographic and clinicopathological characteristic and the associations with DNAm age for 252 CSCC patients
Characteristics | Total (%) | Epigenetic age (0-year cut-off) | Pa | |
|---|---|---|---|---|
DNAmAge-ACC | DNAmAge-DEC | |||
(N = 148) | (N = 104) | |||
Age (years) | ||||
 Continuousb | 252 (100) | 45.6 ± 12.9 | 53.5 ± 15.5 | < 0.001 |
 Category (median) | ||||
  < 47 | 122 (48) | 89 (60) | 33 (32) | < 0.001 |
  ≥ 47 | 130 (52) | 59 (40) | 71 (68) |  |
BMI (WHO) | Â | Â | Â | 0.763 |
  < 18.5 | 9 (4) | 6 (4) | 3 (3) |  |
  18.5–25 | 74 (29) | 43 (29) | 31 (30) |  |
  25–30 | 56 (22) | 31 (21) | 25 (24) |  |
  > 30 | 72 (29) | 46 (31) | 26 (25) |  |
  Missing | 41 (16) | 22 (15) | 19 (18) |  |
Race | Â | Â | Â | 1.000 |
 White | 169 (67) | 99 (67) | 70 (67) |  |
 Others | 52 (21) | 31 (21) | 21 (20) |  |
 Missing | 31 (12) | 18 (12) | 13 (13) |  |
Ethnicity | Â | Â | Â | 0.222 |
 Hispanic or Latino | 20 (8) | 15 (10) | 5 (5) |  |
 Not Hispanic or Latino | 140 (56) | 81 (55) | 59 (57) |  |
 Missing | 92 (36) | 52 (35) | 40 (38) |  |
Stage | Â | Â | Â | 0.878 |
 I + II | 187 (74) | 112 (76) | 75 (72) |  |
 III + IV | 57 (23) | 33 (22) | 24 (23) |  |
 Missing | 8 (3) | 3 (2) | 5 (5) |  |
Tumor status | Â | Â | Â | 0.025 |
 With tumor | 68 (27) | 34 (23) | 34 (33) |  |
 Tumor free | 161 (64) | 107 (72) | 54 (52) |  |
 Missing | 23 (9) | 7 (5) | 16 (15) |  |
Treatment outcomec | Â | Â | Â | 0.007 |
 Response | 150 (60) | 98 (66) | 52 (50) |  |
 Non-response | 25 (10) | 9 (6) | 16 (15) |  |
 Missing | 77 (30) | 41 (28) | 36 (35) |  |
Menopause | Â | Â | Â | 0.004 |
 Post | 70 (28) | 31 (21) | 39 (38) |  |
 Pre | 96 (38) | 64 (43) | 32 (31) |  |
 Missing | 86 (34) | 53 (36) | 33 (31) |  |
HPV | Â | Â | Â | 0.018 |
 Positive | 238 (94) | 144 (98) | 94 (90) |  |
 Negative | 10 (4) | 2 (1) | 8 (8) |  |
 Missing | 4 (2) | 2 (1) | 2 (2) |  |