Fig. 4

H3K27me3 expression in primary melanomas is associated with positive sentinel lymph node and tumor thickness. a Association of sentinel lymph node status with H3K27me3 IHC expression (in %) in primary melanomas. Significance was determined by Mann–Whitney U test for two unpaired groups (p = .020). b Association of tumor thickness in mm (grouped into T1-T4) with H3K27me3 expression (in %) in primary melanomas. Significance was determined by analysis of variance by Kruskal–Wallis test (p = .044). None of the pairwise comparisons reached significance when Bonferroni-adjusted alphas were applied. c Correlation of tumor thickness in mm and percentage of H3K27me3 positive melanoma cells in primary melanomas. Significance was determined by Spearman’s rank correlation test (p = .034).