Fig. 4

Alterations in DNA methylation levels following 3, 15 and 15 + 3 fractional doses. a Unsupervised clustering of methylation beta values. b DNA methylation age. c Number of hypomethylated (white) and hypermethylated (grey) DMPs observed in the IR samples compared with unirradiated samples. Error bars represent standard error of mean. To address the comparability of the cells between different passages, experiments were performed at both mid and late passages for both control and 3 FDIR