A DNA methylation signature to improve survival prediction of gastric cancer

Clinical Epigenetics

Table 1 Ten individual genes of the DNA methylation signature associated with overall survival of gastric cancer patients

Gene symbol	Gene name	Chr	Coefficient	P value	Associated with DNA methylation
CLDN2	Claudin 2	Xq22.3	4.513	0.044	NR
SMKR1	Small lysine rich protein 1	7q32.1	− 2.918	0.079	NR
NFE2L3	Nuclear factor, erythroid 2 like 3	7p15.2	4.152	0.102	BC [34]
SCNN1B	Sodium channel epithelial 1 beta subunit	16p12.2	2.542	0.102	GC [35] and CCRCC [36, 37]
RBPMS2	RNA binding protein, mRNA processing factor 2	15q22.31	4.765	0.044	NR
JPH2	Junctophilin 2	20q13.12	− 8.525	0.006	NR
COL4A5	Collagen type IV alpha 5 chain	Xq22.3	− 4.225	0.001	CRC [38]
ARL4D	ADP ribosylation factor like GTPase 4D	17q21.31	− 2.367	0.110	NR
GBP6	Guanylate binding protein family member 6	1p22.2	− 7.193	0.000	NR
PPP1R14A	Protein phosphatase 1 regulatory inhibitor subunit 14A	19q13.2	− 2.845	0.066	CRC [39] and ESSC [40]

NR not reported, BC breast cancer, GC gastric cancer, CCRCC clear cell renal cell carcinoma, CRC colorectal cancer, ESSC esophageal squamous cell carcinoma

ISSN: 1868-7083