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Table 2 DMR-associated gene pathways or gene sets.

From: Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility

Pathway or gene set name Total # of neighbors Pathology gene set pathway Overlap Percent overlap Overlapping genes p value
Protein regulators of autism 313 Autism 19 6 RBFOX1, CD5, CCR5, GRIN1, GPHN, SLC7A5, SNTG2, RELN, ARHGAP32, OPRM1, DLGAP2, DIAPH3, CACNA1A, KCNMA1, TSHZ3, SLC25A12, NRXN3, SEMA3F, RORA 9.02E−05
Protein regulators of intellectual disability 616 Intellectual disability 28 4 SRGAP3, ERBB4, DMD, TG, AHI1, ANKRD11, CHL1, ST3GAL5, BCKDK, CDK19, DLGAP2, NARS2, PHF21A, KDM2B, CAMTA1, MCPH1, CREBBP, ARHGEF10, TCF4, LIMK1, STIM1, RELN, PRMT7, DPYSL2, SORL1, LRMDA, CDH18, EXOC4 3.42E−04
Protein regulators of neurodevelopmental disorder 273 Neurodevelopmental disorder 16 5 RBFOX1, SRGAP3, GRIN1, LIMK1, AHI1, DOCK3, ANKS1B, ELP4, ANKRD11, RELN, DPYSL2, ST3GAL5, AGAP1, MCPH1, CREBBP, TCF4 4.70E−04
Protein regulators of psychiatric disorder 538 Psychiatric disorder 25 4 GRIN2B, PDE2A, ERBB4, AHI1, CCKBR, ANKS1B, DLGAP1, CCDC141, OPRM1, PDLIM5, GABBR1, SORCS2, CREBBP, ARHGEF10, TCF4, DNMT1, RBFOX1, GPHN, USP46, RELN, DPYSL2, ADRA2C, IMMP2L, NRXN3, ALK 5.12E−04
Protein regulators of intellectual impairment 18 Intellectual impairment 4 21 GRIN2B, GRIN1, DMD, RELN 5.95E−04
Protein regulators of estrogen receptor-positive breast cancer 86 Estrogen receptor-positive breast cancer 8 9 KDM6B, PPARG, ERBB4, PIK3CD, NDRG1, CREBBP, SLC7A5, STIM1 6.90E−04
Protein regulators of behavioral disorder 147 Behavioral disorder 10 6 GRIN2B, GRIN1, ERBB4, PARK7, STX1A, RORA, DNMT1, TMEM173, AP2B1, OPRM1 1.80E−03
Protein regulators of severe visual impairment 14 Severe visual impairment 3 20 PAX2, AIPL1, MERTK 3.39E−03
  1. The pathway total number of neighbors for genes, pathology gene set pathway, overlapping genes, percent overlap, overlapping gene symbols and statistical p value are presented