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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancer

Fig. 2Fig. 2Fig. 2

The expression of miR-129-2-3p in GC and the impact on cell functions. a The expression of miR-129-2-3p was significantly lower in tumor tissues in 26 cases and higher in 8 cases, while the rest of the cases did not show statistical significance. b Transfection efficiency was tested by qPCR. c The proliferation capacity of MGC80-3, SGC-7901, HGC-27 and SNU-719 was significantly enhanced after transfection with inhibitor compared to NC while attenuated after transfection with mimics. d Comparing to DMSO, the proliferation ability of all these cell lines was sabotaged after treated with the demethylator, 5-Aza-CdR, at 1.5 μmol/L for 3 days. e, f, h, i The migration and invasion ability of the GC cells was significantly enhanced after transfected with inhibitor while attenuated after transfection with mimics. g, j Comparing to DMSO, the migration and invasion capacity of the GC cells was diminished after treatment of 5-Aza-CdR at 1.5 μmol/L for 3 days. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001

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