Reproductive technologies, female infertility, and the risk of imprinting-related disorders

Clinical Epigenetics

Table 1 Risk of imprinting-related diseases according to mode of conception and type of female infertility in multivariate analysis

	Total children	Children with at least one imprinting-related disease		Adjusted OR^a	95% CI		p
	N	N	%	Adjusted OR^a	95% CI		p
Mode of conception
NC	3,417,089	3478	0.10	1
Fresh-ET	45,303	72	0.16	1.32	1.04	1.69	0.02
FET	18,885	23	0.12	1.04	0.69	1.57	0.86
IUI	20,218	22	0.11	0.97	0.63	1.47	0.87
Female infertility
Endometriosis	37,398	59	0.16	1.38	1.06	1.80	0.02
PCOS	6977	12	0.17	1.35	0.76	2.39	0.30
POI	1411	5	0.35	2.42	0.99	5.91	0.05

CI confidence interval, Fresh-ET fresh embryo transfer, FET frozen embryo transfer, IUI intrauterine insemination, NC natural conception, OR odds ratio, PCOS polycystic ovary syndrome, POI primary ovarian insufficiency
^aAnalyses were adjusted for maternal parameters: age, primiparity, smoking, obesity, history of high blood pressure or diabetes, and newborn sex

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