Clinical Epigenetics

Table 5 Model summary for the effects of Braak staging on the β values at one of the representative CpG probes (cg26354017)

From: Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer’s disease and implicate its dynamic role in disease progression

dx	Effects						Model statistics
dx	variant	Estimate	SE	t value	Pr( >\|t\|)	Signif. codes	Model statistics
Control	(Intercept)	0.3302	0.1194	2.767	0.006	**	Residual SD	0.1008
	Braak	0.0039	0.0064	0.602	0.548		Multiple r²	0.8457
	rs708727	0.3340	0.0143	23.379	< 2e−16	***	Adjusted r²	0.8419
	rs960603	0.0095	0.0140	0.682	0.496		F-statistic	226.9 (5/207 DF)
	msex	0.0043	0.0147	0.290	0.772		p value	< 2.2E−16
	age_death	−0.0016	0.0014	−1.123	0.263
MCI	(Intercept)	0.2988	0.1729	1.73	0.086		Residual SD	0.1016
	Braak	0.0133	0.0082	1.63	0.106		Multiple r²	0.8476
	rs708727	0.3446	0.0182	18.98	< 2e−16	***	Adjusted r²	0.8423
	rs960603	−0.0203	0.0183	−1.11	0.269		F-statistic	159.1 (5/143 DF)
	msex	0.0245	0.0175	1.40	0.164		p value	< 2.2E−16
	age_death	−0.0014	0.0020	−0.70	0.483
AD	(Intercept)	0.2564	0.1636	1.57	0.118		Residual SD	0.092
	Braak	0.0166	0.0056	2.95	0.004	**	Multiple r²	0.8813
	rs708727	0.3362	0.0146	23.06	< 2e−16	***	Adjusted r²	0.8788
	rs960603	0.0102	0.0142	0.72	0.472		F-statistic	351.9 (5/237 DF)
	msex	−0.0140	0.0130	−1.08	0.282		p value	< 2.2E−16
	age_death	−0.0013	0.0018	−0.68	0.496
All	(Intercept)	0.3262	0.0795	4.10	4.66e−05	***	Residual SD	0.097
	Braak	0.0108	0.0034	3.16	0.0016	**	Multiple r²	0.8590
	rs708727	0.3376	0.0087	38.79	< 2e−16	***	Adjusted r²	0.8578
	rs960603	0.0038	0.0086	0.44	0.657		F-statistic	729.9 (5/599 DF)
	msex	0.0015	0.0085	0.18	0.861		p value	< 2.2E−16
	age_death	−0.0018	0.0009	−1.86	0.063

Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘’ 1

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ISSN: 1868-7083

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