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Table 5 Model summary for the effects of Braak staging on the β values at one of the representative CpG probes (cg26354017)

From: Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer’s disease and implicate its dynamic role in disease progression

dx Effects Model statistics
variant Estimate SE t value Pr( >|t|) Signif. codes
Control (Intercept) 0.3302 0.1194 2.767 0.006 ** Residual SD 0.1008
Braak 0.0039 0.0064 0.602 0.548   Multiple r2 0.8457
rs708727 0.3340 0.0143 23.379  < 2e−16 *** Adjusted r2 0.8419
rs960603 0.0095 0.0140 0.682 0.496   F-statistic 226.9 (5/207 DF)
msex 0.0043 0.0147 0.290 0.772   p value  < 2.2E−16
age_death −0.0016 0.0014 −1.123 0.263    
MCI (Intercept) 0.2988 0.1729 1.73 0.086   Residual SD 0.1016
Braak 0.0133 0.0082 1.63 0.106   Multiple r2 0.8476
rs708727 0.3446 0.0182 18.98  < 2e−16 *** Adjusted r2 0.8423
rs960603 −0.0203 0.0183 −1.11 0.269   F-statistic 159.1 (5/143 DF)
msex 0.0245 0.0175 1.40 0.164   p value  < 2.2E−16
age_death −0.0014 0.0020 −0.70 0.483    
AD (Intercept) 0.2564 0.1636 1.57 0.118   Residual SD 0.092
Braak 0.0166 0.0056 2.95 0.004 ** Multiple r2 0.8813
rs708727 0.3362 0.0146 23.06  < 2e−16 *** Adjusted r2 0.8788
rs960603 0.0102 0.0142 0.72 0.472   F-statistic 351.9 (5/237 DF)
msex −0.0140 0.0130 −1.08 0.282   p value  < 2.2E−16
age_death −0.0013 0.0018 −0.68 0.496    
All (Intercept) 0.3262 0.0795 4.10 4.66e−05 *** Residual SD 0.097
Braak 0.0108 0.0034 3.16 0.0016 ** Multiple r2 0.8590
rs708727 0.3376 0.0087 38.79  < 2e−16 *** Adjusted r2 0.8578
rs960603 0.0038 0.0086 0.44 0.657   F-statistic 729.9 (5/599 DF)
msex 0.0015 0.0085 0.18 0.861   p value  < 2.2E−16
age_death −0.0018 0.0009 −1.86 0.063    
  1. Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘’ 1
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Clinical Epigenetics

ISSN: 1868-7083

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