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Table 4 Model summary for the LME modeling between age and the β values at one of the representative CpG probes (cg14893161). Fixed effects from age, sex, allelic dosages of the two SNPs and random effects from subject (RID), chip slide and array are shown

From: Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer’s disease and implicate its dynamic role in disease progression

dx Fixed effects Random effects
Variant Estimate SE df t value Pr( >|t|) Signif. codes Groups Name Variance SD
Control (Intercept) 0.2544 0.1185 312.70 2.15 0.0326 * RID (Intercept) 0.0154 0.1239
Age 0.0010 0.0014 340.10 0.68 0.4948   Slide (Intercept) 0.0030 0.0544
Sex −0.0299 0.0218 158.80 −1.37 0.1715   Array (Intercept) 0.0000 0.0025
rs708727 0.2392 0.0203 154.90 11.76  < 2E−16 *** Residual   0.0017 0.0408
rs960603 0.0018 0.0215 159.60 0.08 0.9339      
MCI (Intercept) 0.2973 0.1064 351.20 2.795 0.00547 ** RID (Intercept) 0.0123 0.1108
Age −0.0010 0.0013 385.40 −0.710 0.4782   Slide (Intercept) 0.0089 0.0943
Sex 0.0071 0.0221 168.30 0.321 0.7482   Array (Intercept) 0.0001 0.0077
rs708727 0.2676 0.0210 167.00 12.742  < 2E−16 *** Residual   0.0014 0.0374
rs960603 −0.0038 0.0206 165.30 −0.187 0.8520      
AD (Intercept) −0.2992 0.1659 117.40 −1.803 0.07391   RID (Intercept) 0.0156 0.1250
Age 0.0056 0.0020 122.80 2.775 0.00638 ** Slide (Intercept) 0.0081 0.0899
Sex 0.0696 0.0351 83.48 1.983 0.0506   Array (Intercept) 0.0000 0.0050
rs708727 0.2722 0.0379 69.96 7.179 5.90E−10 *** Residual   0.0019 0.0432
rs960603 0.0006 0.0335 77.22 0.019 0.9849      
All stable (Intercept) 0.0996 0.0715 798.00 1.391 0.1645   RID (Intercept) 0.0132 0.1150
Age 0.0015 0.0009 864.10 1.733 0.0835   Slide (Intercept) 0.0080 0.0897
Sex 0.0089 0.0144 442.00 0.622 0.5343   Array (Intercept) 0.0000 0.0054
rs708727 0.2831 0.0128 340.10 22.051  < 2e−16 *** Residual   0.0017 0.0408
rs960603 0.0038 0.0131 374.50 0.288 0.7733      
  1. Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘’ 1