Clinical Epigenetics

Table 4 Model summary for the LME modeling between age and the β values at one of the representative CpG probes (cg14893161). Fixed effects from age, sex, allelic dosages of the two SNPs and random effects from subject (RID), chip slide and array are shown

From: Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer’s disease and implicate its dynamic role in disease progression

dx	Fixed effects							Random effects
dx	Variant	Estimate	SE	df	t value	Pr( >\|t\|)	Signif. codes	Groups	Name	Variance	SD
Control	(Intercept)	0.2544	0.1185	312.70	2.15	0.0326	*	RID	(Intercept)	0.0154	0.1239
	Age	0.0010	0.0014	340.10	0.68	0.4948		Slide	(Intercept)	0.0030	0.0544
	Sex	−0.0299	0.0218	158.80	−1.37	0.1715		Array	(Intercept)	0.0000	0.0025
	rs708727	0.2392	0.0203	154.90	11.76	< 2E−16	***	Residual		0.0017	0.0408
	rs960603	0.0018	0.0215	159.60	0.08	0.9339
MCI	(Intercept)	0.2973	0.1064	351.20	2.795	0.00547	**	RID	(Intercept)	0.0123	0.1108
	Age	−0.0010	0.0013	385.40	−0.710	0.4782		Slide	(Intercept)	0.0089	0.0943
	Sex	0.0071	0.0221	168.30	0.321	0.7482		Array	(Intercept)	0.0001	0.0077
	rs708727	0.2676	0.0210	167.00	12.742	< 2E−16	***	Residual		0.0014	0.0374
	rs960603	−0.0038	0.0206	165.30	−0.187	0.8520
AD	(Intercept)	−0.2992	0.1659	117.40	−1.803	0.07391		RID	(Intercept)	0.0156	0.1250
	Age	0.0056	0.0020	122.80	2.775	0.00638	**	Slide	(Intercept)	0.0081	0.0899
	Sex	0.0696	0.0351	83.48	1.983	0.0506		Array	(Intercept)	0.0000	0.0050
	rs708727	0.2722	0.0379	69.96	7.179	5.90E−10	***	Residual		0.0019	0.0432
	rs960603	0.0006	0.0335	77.22	0.019	0.9849
All stable	(Intercept)	0.0996	0.0715	798.00	1.391	0.1645		RID	(Intercept)	0.0132	0.1150
	Age	0.0015	0.0009	864.10	1.733	0.0835		Slide	(Intercept)	0.0080	0.0897
	Sex	0.0089	0.0144	442.00	0.622	0.5343		Array	(Intercept)	0.0000	0.0054
	rs708727	0.2831	0.0128	340.10	22.051	< 2e−16	***	Residual		0.0017	0.0408
	rs960603	0.0038	0.0131	374.50	0.288	0.7733

Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘’ 1

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ISSN: 1868-7083

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