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Table 2 Distribution of low, intermediate and highly methylated DNA methylation sites between different genomic elements in NEC and non-NEC colon tissues

From: Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis

Feature Methylation Colon
Percent NEC (%)a Non-NEC (%)a Chi-square2b df p
Promoter < 20 37,158 (21.0) 41,311 (23.4) 937 2 < 0.0001
20–80 66,839 (37.8) 71,457 (40.4)
> 80 72,745 (41.2) 63,974 (36.2)
Exonic < 20 11,149 (4.6) 12,921 (5.4) 3926 2 < 0.0001
20–80 103,599 (42.9) 123,568 (51.2)
> 80 126,717 (52.5) 104,976 (43.5)
Intronic < 20 78,867 (1.8) 110,129 (2.5) 65,796 2 < 0.0001
20–80 1,849,085 (41.6) 2,196,549 (49.4)
> 80 2,519,124 (56.6) 2,140,398 (48.1)
CpG Island < 20 14,441 (46.1) 14,521 (46.3) 1.1 2 0.57
20–80 6607 (21.1) 6651 (21.2)
> 80 10,289 (32.8) 10,165 (32.4)
CpG Shore < 20 54,460 (15.6) 62,519 (17.9) 1362 2 < 0.0001
20–80 123,299 (35.3) 129,751 (37.2)
> 80 171,130 (49) 156,619 (44.9)
Enhancer < 20 913 (7.8) 1095 (9.3) 89 2 < 0.0001
20–80 5830 (49.6) 6339 (54.0)
> 80 5006 (42.6) 4315 (36.7)
Intergenic < 20 72,468 (1.5) 106,195 (2.2) 74,182 2 < 0.0001
20–80 2,472,995 (51.4) 2,850,249 (59.3)
> 80 2,261,348 (47.0) 1,850,367 (38.5)
CpG Island + CpG Shore < 20 68,901 (18.1) 77,040 (20.3) 1228 2 < 0.0001
20–80 129,906 (34.2) 136,402 (35.9)
> 80 181,419 (47.7) 166,784 (43.9)
Exons + Introns < 20 90,016 (1.9) 123,050 (2.6) 69,507 2 < 0.0001
20–80 1,952,684 (41.6) 2,320,117 (49.5)
> 80 2,645,841 (56.4) 2,245,374 (47.9)
All < 20 191,444 (2.0) 261,637 (2.7) 145,070 2 < 0.0001
20–80 4,407,199 (45.6) 5,166,249 (53.5)
> 80 5,060,312 (52.4) 4,231,069 (43.8)
  1. df degrees of freedom, p probability
  2. aCount (percent)
  3. bPearson's Chi-squared test