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Table 4 Pooled hazard ratios for the association between methylation levels at the ten most VMRs and overall survival: meta-analysis of the MCCS and TCGA results

From: Association of variably methylated tumour DNA regions with overall survival for invasive lobular breast cancer

   

Adjusted for age

Adjusted for age and stage

Gene*

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

APC

1.24 (1.07–1.44)

0.004

1.20 (1.04–1.39)

0.01

1.18 (1.02–1.36)

0.03

TMEM101

1.19 (1.00–1.42)

0.05

1.17 (0.99–1.39)

0.06

1.23 (1.02–1.48)

0.03

ISM1

1.38 (1.05–1.80)

0.02

1.09 (0.84–1.42)

0.50

1.03 (0.77–1.36)

0.83

ASCL2

1.19 (0.88–1.61)

0.24

0.99 (0.74–1.33)

0.96

1.08 (0.81–1.45)

0.57

HIST3H2A

1.30 (1.08–1.57)

0.004

1.15 (0.95–1.37)

0.14

1.09 (0.91–1.31)

0.33

NKX6

1.40 (1.13–1.74)

0.002

1.21 (0.98–1.50)

0.08

1.18 (0.95–1.46)

0.13

HCG4P3

1.45 (1.13–1.85)

0.003

1.30 (1.00–1.67)

0.04

1.37 (1.05–1.79)

0.02

HES5

1.15 (0.95–1.40)

0.15

1.12 (0.92–1.36)

0.25

1.13 (0.92–1.38)

0.23

CELF2

1.34 (1.13–1.60)

0.0006

1.18 (1.00–1.40)

0.05

1.21 (1.02–1.43)

0.02

EFCAB4B

1.12 (0.95–1.32)

0.17

1.05 (0.89–1.22)

0.57

1.05 (0.90–1.23)

0.49

  1. *Gene: Gene associated with the variably methylated regions (VMRs), most of the VMRs were located in the promoter region of the genes, HR hazard ratio, CI confidence interval
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Clinical Epigenetics

ISSN: 1868-7083

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