Fig. 5

Integration of changes in DNA methylation and changes in gene expression levels during SIV infection. a AGM and b MAC Venn diagrams showing the number of differentially methylated genes (DMG) and differentially expressed genes (DEG). Percentages within parentheses. Only genes that were present in both microarray types were included. Example plots showing methylation levels and expression levels for c AGM IL31 (cg09750599) (n = 4–10), d MAC FOXP1 (cg05384123) and e MAC SGMS1 (cg10631515) (n = 3–13). Methylation is indicated with blue (right axis) and expression with red (left axis). Mean levels are shown for lymph node (LN, dark) and blood (light). Baseline levels are denoted as day 0. *Indicates significant difference compared to pre-infection as described in the methods, with the color corresponding to its condition