Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellular programming

Table 1 Total content and de novo synthesis of FAs and cholesterol

	FA type	Group (p values)	Time (p values)	Group * time (p values)
Total production	Total C14:0	0.019	0.012	0.066
	Total C16:0	0.019	0.013	0.068
	Total C16:1	0.028	0.016	0.089
	Total C18:1	0.033	0.024	0.159
	Total C18:2	0.050	0.038	0.273
	Cholesterol	0.580	0.045	0.339
De novo synthesis	De novo synthesis C14:0	0.009	0.005	0.094
	De novo synthesis C16:0	0.012	0.007	0.071
	De novo synthesis C16:1	0.026	0.019	0.196
	De novo synthesis C18:1	0.020	0.012	0.152
	Cholesterol	0.067	0.035	0.254

Group represents PCOS versus control difference. Time represents day 7 versus day 12 difference. Group * time represents the interaction term between female group and time (day 7 vs day 12). Bold values indicate p < 0.05

ISSN: 1868-7083