Table 2 Description of the study population. Information about TTR amyloidogenic mutations, sex, age, epigenetically determined smoking status (never smoker, NS; former smoker, FS; current smoker, CS), and epigenetically estimated ranges of T cells (CD8T and CD4T), natural killer cells (NK), B cells, monocytes (Mono) and granulocytes (Gran) are reported
TTR mutation | N | Sex Female (%) | Age median (Min–Max) | Smoking | CD8T Median (Min –Max) | CD4T median (Min–Max) | NK median (Min–Max) | B cell median (Min–Max) | Mono median (Min–Max) | Gran median (Min–Max) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
NS | FS | CS | ||||||||||
Cases | ||||||||||||
Val30Met | 33 | 10 (30) | 65 (31–88) | 1 | 23 | 9 | 0.033 (−3.24 × 10–20–0.131) | 0.118 (1.1 × 10–2–0.21) | 0.033 (−3.81 × 10–19–0.127) | 1.52 × 10–3 (−5.55 × 10–19–0.066) | 0.082 (0.038–0.147) | 0.634 (0.551–0.824) |
Phe64Leu | 8 | 1 (12) | 70 (48–75) | 0 | 4 | 4 | 4.02 × 10–3 (1.07 × 10–18–1.112) | 0.127 (6.9 × 10–2–0.228) | 0.014 (1.96 × 10–20–0.099) | 3.13 × 10–3 (−2.17 × 10–19–0.021) | 0.085 (0.057–0.107) | 0.65 (0.46–0.704) |
Ala120Ser | 2 | 2 (100) | 67–68 | 0 | 2 | 0 | −3.34 × 10–20–0 | 0.068–0.11 | 8.1 × 10–3–1.28 × 10–1 | 0–5.1 × 10–3 | 0.092–0.11 | 0.56–0.74 |
Ile68Leu | 3 | 0 | 53 (30–62) | 0 | 0 | 3 | 0 | 0.142 (0.07–0.16) | 0.038 (0.013–0.041) | 4.4 × 10–3 (3.8 × 10–3–5.1 × 10–3) | 0.083 (0.096–0.147) | 0.59 (0.603–0.73) |
Val122Ile | 1 | 0 | 80 | 0 | 0 | 1 | 0 | 0.23 | 0.042 | 0.005 | 0.071 | 0.55 |
rs36204272* | 1 | 0 | 65 | 0 | 1 | 0 | 0.069 | 0.14 | 0.052 | 0.006 | 0.129 | 0.505 |
Controls | ||||||||||||
– | 32 | 19 (59) | 37 (20–76) | 0 | 27 | 5 | 0.015 (8.45 × 10–19–0.13) | 0.16 (0.045–0.34) | 0.044 (−2.68 × 10–19–0.18) | 0.014 (1.08 × 10–19–0.091) | 0.092 (0.051–0.13) | 0.571 (0.41–0.76) |