Table 1 Enrichments for gene ontologies (GO) of biological processes and for Reactome and KEGG molecular pathways (HSA and hsa, respectively)
ID | Description | Proteins | False discovery rate q value |
|---|---|---|---|
hsa05010 | Alzheimer's disease | APP,BACE1,BACE2 | 2.2E-04 |
HSA-2029481 | FCGR activation | FYN,IGHV3-11 | 7.9E-04 |
HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | FYN,IGHV3-11 | 7.9E-04 |
HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | FYN,IGHV3-11 | 0.002 |
GO: 0006509 | Membrane protein ectodomain proteolysis | BACE1,BACE2 | 0.007 |
GO: 0050435 | Amyloid-beta metabolic process | BACE1,BACE2 | 0.007 |
GO: 1902950 | Regulation of dendritic spine maintenance | APP,FYN | 0.007 |
HSA-977225 | Amyloid fiber formation | APP,BACE1 | 0.008 |
GO: 1904645 | Response to amyloid-beta | APP,FYN | 0.009 |
HSA-109582 | Hemostasis | APP,FYN,IGHV3-11 | 0.010 |
GO: 0106027 | Neuron projection organization | APP,FYN | 0.010 |
GO: 1900449 | Regulation of glutamate receptor signaling pathway | APP,FYN | 0.010 |
HSA-202733 | Cell surface interactions at the vascular wall | FYN,IGHV3-11 | 0.010 |
GO: 0061098 | Positive regulation of protein tyrosine kinase activity | APP,FYN | 0.017 |
GO: 1903201 | Regulation of oxidative stress-induced cell death | APP,FYN | 0.017 |
GO: 0006897 | Endocytosis | APP,FYN,IGHV3-11 | 0.018 |
GO: 0007631 | Feeding behavior | APP,FYN | 0.018 |
GO: 0016358 | Dendrite development | APP,FYN | 0.018 |
GO: 0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | FYN,IGHV3-11 | 0.018 |
GO: 1901216 | Positive regulation of neuron death | APP,FYN | 0.018 |
GO: 1903426 | Regulation of reactive oxygen species biosynthetic process | APP,FYN | 0.018 |
GO:1900180 | Regulation of protein localization to nucleus | APP,FYN | 0.020 |
GO: 0007612 | Learning | APP,FYN | 0.027 |
GO: 0031347 | Regulation of defense response | APP,FYN,IGHV3-11 | 0.027 |
GO: 2001056 | Positive regulation of cysteine-type endopeptidase activity | APP,FYN | 0.027 |
GO:0030162 | Regulation of proteolysis | APP,FYN,IGHV3-11 | 0.031 |
GO: 0051897 | Positive regulation of protein kinase B signaling | APP,FYN | 0.031 |
GO: 2000377 | Regulation of reactive oxygen species metabolic process | APP,FYN | 0.031 |
HSA-168249 | Innate Immune System | APP,FYN,IGHV3-11 | 0.032 |
HSA-76002 | Platelet activation, signaling and aggregation | APP,FYN | 0.032 |
GO: 0050808 | Synapse organization | APP,FYN | 0.034 |
GO: 1901215 | Negative regulation of neuron death | APP,FYN | 0.034 |
GO: 0002684 | Positive regulation of immune system process | APP,FYN,IGHV3-11 | 0.037 |
GO: 0050776 | Regulation of immune response | APP,FYN,IGHV3-11 | 0.037 |
GO: 0002252 | Immune effector process | APP,FYN,IGHV3-11 | 0.041 |
GO: 0007411 | Axon guidance | APP,FYN | 0.041 |
GO: 0019538 | Protein metabolic process | APP,BACE1,BACE2,FYN,IGHV3-11 | 0.043 |
GO: 0006959 | Humoral immune response | APP,IGHV3-11 | 0.045 |