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Table 1 Enrichments for gene ontologies (GO) of biological processes and for Reactome and KEGG molecular pathways (HSA and hsa, respectively)

From: Epigenetic profiling of Italian patients identified methylation sites associated with hereditary transthyretin amyloidosis

ID Description Proteins False discovery rate q value
hsa05010 Alzheimer's disease APP,BACE1,BACE2 2.2E-04
HSA-2029481 FCGR activation FYN,IGHV3-11 7.9E-04
HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization FYN,IGHV3-11 7.9E-04
HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers FYN,IGHV3-11 0.002
GO: 0006509 Membrane protein ectodomain proteolysis BACE1,BACE2 0.007
GO: 0050435 Amyloid-beta metabolic process BACE1,BACE2 0.007
GO: 1902950 Regulation of dendritic spine maintenance APP,FYN 0.007
HSA-977225 Amyloid fiber formation APP,BACE1 0.008
GO: 1904645 Response to amyloid-beta APP,FYN 0.009
HSA-109582 Hemostasis APP,FYN,IGHV3-11 0.010
GO: 0106027 Neuron projection organization APP,FYN 0.010
GO: 1900449 Regulation of glutamate receptor signaling pathway APP,FYN 0.010
HSA-202733 Cell surface interactions at the vascular wall FYN,IGHV3-11 0.010
GO: 0061098 Positive regulation of protein tyrosine kinase activity APP,FYN 0.017
GO: 1903201 Regulation of oxidative stress-induced cell death APP,FYN 0.017
GO: 0006897 Endocytosis APP,FYN,IGHV3-11 0.018
GO: 0007631 Feeding behavior APP,FYN 0.018
GO: 0016358 Dendrite development APP,FYN 0.018
GO: 0038096 Fc-gamma receptor signaling pathway involved in phagocytosis FYN,IGHV3-11 0.018
GO: 1901216 Positive regulation of neuron death APP,FYN 0.018
GO: 1903426 Regulation of reactive oxygen species biosynthetic process APP,FYN 0.018
GO:1900180 Regulation of protein localization to nucleus APP,FYN 0.020
GO: 0007612 Learning APP,FYN 0.027
GO: 0031347 Regulation of defense response APP,FYN,IGHV3-11 0.027
GO: 2001056 Positive regulation of cysteine-type endopeptidase activity APP,FYN 0.027
GO:0030162 Regulation of proteolysis APP,FYN,IGHV3-11 0.031
GO: 0051897 Positive regulation of protein kinase B signaling APP,FYN 0.031
GO: 2000377 Regulation of reactive oxygen species metabolic process APP,FYN 0.031
HSA-168249 Innate Immune System APP,FYN,IGHV3-11 0.032
HSA-76002 Platelet activation, signaling and aggregation APP,FYN 0.032
GO: 0050808 Synapse organization APP,FYN 0.034
GO: 1901215 Negative regulation of neuron death APP,FYN 0.034
GO: 0002684 Positive regulation of immune system process APP,FYN,IGHV3-11 0.037
GO: 0050776 Regulation of immune response APP,FYN,IGHV3-11 0.037
GO: 0002252 Immune effector process APP,FYN,IGHV3-11 0.041
GO: 0007411 Axon guidance APP,FYN 0.041
GO: 0019538 Protein metabolic process APP,BACE1,BACE2,FYN,IGHV3-11 0.043
GO: 0006959 Humoral immune response APP,IGHV3-11 0.045