Table 1 Detection rates of both assays according to histological/cytological and hrHPV findings (n = 195)
From: Triage of hrHPV-positive women: comparison of two commercial methylation-specific PCR assays
GynTect® | QIAsure Methylation Test | P value for comparison of detection rate | |||
|---|---|---|---|---|---|
Test positive | Detection rate [%] (95% CI) | Test positive | Detection rate [%] (95% CI) | ||
hrHPV + | |||||
CxCa (n = 2) | 2 | 2/2* | 2 | 2/2* | – |
CIS (n = 5) | 5 | 5/5* | 5 | 5/5* | – |
CIN3 (n = 35) | 21 | 60.0 (42.1–76.1) | 26 | 74.3 (56.7–87.5) | 0.125 |
CIN2 (n = 18) | 6 | 33.3 (13.3–59.0) | 5 | 27.8 (9.7–53.5) | 1.000 |
CIN1 (n = 15) | 2 | 13.3 (1.7–40.5) | 4 | 26.7 (7.8–55.1) | 0.500 |
no CIN (n = 21) | 6 | 28.6 (11.3–52.2) | 11 | 52.4 (29.8–74.3) | 0.125 |
NILM (n = 53) | 3 | 5.7 (1.2–15.7) | 14 | 26.4 (15.3–40.3) | 0.003 |
hrHPV − | |||||
NILM (n = 46) | 1 | 2.2 (0.1–11.5) | 11 | 23.9 (12.6–38.8) | 0.006 |