Fig. 4

Differential methylation of potential key genomic features. Box plots showing the range of methylation percentages for the patients and controls with the range of the boxes indicating the limits of the upper third and lower third quartile of the data, with the mean indicated by the horizontal line within the box. Individual methylation percentages are shown as single data points. a The top five differentially methylated fragments within promoter or gene regions, and b the top differentially methylated individual cytosines within promoter or gene regions. Gene regions are indicated with a ‘G’ and promoter regions with a ‘P’ in the feature ID. Multiple cytosines from the same feature are indicated with a ‘C’ and an identifying number. Multiple fragments from the same feature are indicated with a ‘F’. Control boxes and points are shown in red with patients in blue