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Fig. 3: | Clinical Epigenetics

Fig. 3:

From: DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma

Fig. 3:

5hmC persists at specific oncogenic regions of myeloma subgroups. a MS quantification of 5hmC in myeloma cells of patients belonging to the MMSET (red), CCND1 (blue), hyperdiploid (HD, green) groups and the patients not related to any of the 3 groups (other, gray). b Heatmap of 5hmC-enriched domains specificity among the 40 MM patients and the 5 healthy donors (normal, pink). Color code for patients (in rows) corresponds to that of panel a. Asterisks stand for proximal non-genic loci. c Plot showing the 5hmC-enriched domains that are specifically enriched in patient groups MMSET, CCND1, hyperdiploid and normal plasma cells. Significant domains are colored. d 5hmC, ATAC and H3K27ac signals at the FGFR3-MMSET locus in the MMSET patient group and the non-MMSET patients

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Clinical Epigenetics

ISSN: 1868-7083

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