Fig. 2:

5hmC peaks are organized in large domains and correlate with RNA expression in MM. a Example of two 5hmC-enriched domains at the locus DUSP22-IRF4 and Venn diagram showing the overlap between the top 500 5hmC-enriched domains (patient MM27) and H3K27ac super-enhancers (patient Jin_MM2). b ROSE plot (rank of super-enhancers) of the top 500 H3K27ac super-enhancers (patient Jin_MM2) and 5hmC-enriched domains (patient MM27). c 5hmC signal at 5hmC-enriched domains correlates with RNA expression of their neighbor gene. d 5hmC (this study), ATAC [33], H3K27ac [33] signals and ChromHMM states at the CCND2 genomic locus. The 5hmC signal correlation between the CCND2 gene and its putative enhancer is indicated