Table 5 Mediation effect of DNA methylation and gene expression in the association between smoking and cardio-metabolic traits
Mediator | Outcome | ACME (95% CI) | ADE (95% CI) | Total effect (95% CI) | Prob. Med. (95% CI) | ρ at which ACME is 0a |
|---|---|---|---|---|---|---|
cg03636183 (F2RL3) | ILMN_1773650 (LRRN3) | 0.6835 (0.4731/0.8869) | 1.9603 (1.5832/2.3822) | 2.6438 (2.2907/3.0048) | 0.2585 (0.1767/0.3432) | − 0.3 |
cg06096336 (PSMD1;HTR2B) | ILMN_1773650 (LRRN3) | 0.1237 (0.0263/0.2396) | 2.5202 (2.1796/2.849) | 2.6438 (2.2907/3.0048) | 0.0468 (0.0102/0.0886) | − 0.4 |
cg13708645 (KDM2B) | ILMN_1773650 (LRRN3) | 0.0768 (0.025/0.1408) | 2.5671 (2.2153/2.9309) | 2.6438 (2.2907/3.0048) | 0.0290 (0.0092/0.0533) | − 0.1 |
cg17287155 (AHRR) | ILMN_1773650 (LRRN3) | 0.6357 (0.4798/0.8094) | 2.0081 (1.6771/2.333) | 2.6438 (2.2907/3.0048) | 0.2405 (0.1835/0.3036) | − 0.5 |
cg06096336 (PSMD1;HTR2B) | ILMN_2048591 (LRRN3) | 0.0992 (0.0198/0.1915) | 2.2838 (1.9578/2.5975) | 2.3830 (2.0445/2.721) | 0.0416 (0.0085/0.0779) | − 0.3 |
cg17287155 (AHRR) | ILMN_2048591 (LRRN3) | 0.5004 (0.3828/0.6542) | 1.8826 (1.5691/2.2123) | 2.3830 (2.0445/2.721) | 0.2100 (0.1603/0.2724) | − 0.4 |