Skip to main content

Table 5 Mediation effect of DNA methylation and gene expression in the association between smoking and cardio-metabolic traits

From: Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits

Mediator Outcome ACME (95% CI) ADE (95% CI) Total effect (95% CI) Prob. Med. (95% CI) ρ at which ACME is 0a
cg03636183 (F2RL3) ILMN_1773650 (LRRN3) 0.6835 (0.4731/0.8869) 1.9603 (1.5832/2.3822) 2.6438 (2.2907/3.0048) 0.2585 (0.1767/0.3432) − 0.3
cg06096336 (PSMD1;HTR2B) ILMN_1773650 (LRRN3) 0.1237 (0.0263/0.2396) 2.5202 (2.1796/2.849) 2.6438 (2.2907/3.0048) 0.0468 (0.0102/0.0886) − 0.4
cg13708645 (KDM2B) ILMN_1773650 (LRRN3) 0.0768 (0.025/0.1408) 2.5671 (2.2153/2.9309) 2.6438 (2.2907/3.0048) 0.0290 (0.0092/0.0533) − 0.1
cg17287155 (AHRR) ILMN_1773650 (LRRN3) 0.6357 (0.4798/0.8094) 2.0081 (1.6771/2.333) 2.6438 (2.2907/3.0048) 0.2405 (0.1835/0.3036) − 0.5
cg06096336 (PSMD1;HTR2B) ILMN_2048591 (LRRN3) 0.0992 (0.0198/0.1915) 2.2838 (1.9578/2.5975) 2.3830 (2.0445/2.721) 0.0416 (0.0085/0.0779) − 0.3
cg17287155 (AHRR) ILMN_2048591 (LRRN3) 0.5004 (0.3828/0.6542) 1.8826 (1.5691/2.2123) 2.3830 (2.0445/2.721) 0.2100 (0.1603/0.2724) − 0.4
  1. The table shows the results of mediation analysis, in which current smoking is always used as exposure and is adjusted for age and sex
  2. ACME average causal mediation effect, ADE average direct effect, Prop. Med proportion mediated
  3. aρ at which ACME is 0 indicates how sensitive our model is to the non-unmeasured confounding assumption