|
Mediator
|
Outcome
|
ACME (95% CI)
|
ADE (95% CI)
|
Total effect (95% CI)
|
Prob. Med. (95% CI)
|
ρ at which ACME is 0a
|
|---|
|
cg03636183 (F2RL3)
|
ILMN_1773650 (LRRN3)
|
0.6835 (0.4731/0.8869)
|
1.9603 (1.5832/2.3822)
|
2.6438 (2.2907/3.0048)
|
0.2585 (0.1767/0.3432)
|
− 0.3
|
|
cg06096336 (PSMD1;HTR2B)
|
ILMN_1773650 (LRRN3)
|
0.1237 (0.0263/0.2396)
|
2.5202 (2.1796/2.849)
|
2.6438 (2.2907/3.0048)
|
0.0468 (0.0102/0.0886)
|
− 0.4
|
|
cg13708645 (KDM2B)
|
ILMN_1773650 (LRRN3)
|
0.0768 (0.025/0.1408)
|
2.5671 (2.2153/2.9309)
|
2.6438 (2.2907/3.0048)
|
0.0290 (0.0092/0.0533)
|
− 0.1
|
|
cg17287155 (AHRR)
|
ILMN_1773650 (LRRN3)
|
0.6357 (0.4798/0.8094)
|
2.0081 (1.6771/2.333)
|
2.6438 (2.2907/3.0048)
|
0.2405 (0.1835/0.3036)
|
− 0.5
|
|
cg06096336 (PSMD1;HTR2B)
|
ILMN_2048591 (LRRN3)
|
0.0992 (0.0198/0.1915)
|
2.2838 (1.9578/2.5975)
|
2.3830 (2.0445/2.721)
|
0.0416 (0.0085/0.0779)
|
− 0.3
|
|
cg17287155 (AHRR)
|
ILMN_2048591 (LRRN3)
|
0.5004 (0.3828/0.6542)
|
1.8826 (1.5691/2.2123)
|
2.3830 (2.0445/2.721)
|
0.2100 (0.1603/0.2724)
|
− 0.4
|
- The table shows the results of mediation analysis, in which current smoking is always used as exposure and is adjusted for age and sex
- ACME average causal mediation effect, ADE average direct effect, Prop. Med proportion mediated
- aρ at which ACME is 0 indicates how sensitive our model is to the non-unmeasured confounding assumption
