|
Probe ID
|
Gene IDa
|
Chr. a
|
Trait
|
Model 1
|
Model 2
|
Replication
|
|---|
|
Effect
|
P value
|
Effect
|
P value
|
Effect
|
P value
|
|---|
|
ILMN_1700306
|
OCIAD2
|
4
|
HDL
|
− 0.4114
|
8.39E−07
|
− 0.3573
|
5.15E−05
|
− 0.0040
|
9.20E−05
|
|
ILMN_1761463
|
EFHD2
|
1
|
HDL
|
0.4668
|
1.60E−07
|
0.3576
|
0.00013
|
0.0022
|
1.38E−03
|
|
ILMN_2261416
|
CD3D
|
11
|
TG
|
0.9089
|
2.22E−15
|
0.8328
|
3.84E−12
|
0.3233
|
2.58E−15
|
|
ILMN_2079655
|
KLRB1
|
12
|
TG
|
1.1666
|
6.48E−14
|
1.0518
|
1.01E−10
|
0.3946
|
4.09E−15
|
|
ILMN_1779324
|
GZMA
|
5
|
TG
|
1.0562
|
1.99E−09
|
1.0033
|
6.01E−08
|
0.2734
|
2.06E−13
|
|
ILMN_1761463
|
EFHD2
|
1
|
TG
|
− 0.4238
|
2.59E−09
|
− 0.3434
|
3.54E−06
|
− 0.1298
|
9.99E−13
|
|
ILMN_1700306
|
OCIAD2
|
4
|
TG
|
0.3413
|
3.32E−07
|
0.2998
|
1.93E−05
|
0.1691
|
7.64E−10
|
|
ILMN_1808939
|
RPS6
|
9
|
TG
|
0.6145
|
5.58E−11
|
0.5687
|
7.54E− 09
|
0.3001
|
1.17E−09
|
|
ILMN_1812191
|
C12orf57
|
12
|
TG
|
0.4392
|
1.37E−05
|
0.3897
|
0.00023
|
0.1772
|
1.07E−07
|
|
ILMN_1776181
|
BIRC3
|
11
|
TG
|
0.6940
|
2.86E−10
|
0.6176
|
8.34E−08
|
0.1473
|
4.89E−07
|
|
ILMN_1813836
|
DARS
|
2
|
TG
|
0.2657
|
9.37E−07
|
0.2878
|
4.67E−07
|
0.0894
|
3.18E-06
|
|
ILMN_1669927
|
ICOS
|
2
|
TG
|
0.2859
|
6.88E-06
|
0.2692
|
5.75E-05
|
0.0925
|
2.95E−04
|
|
ILMN_2198878
|
INPP4B
|
4
|
TG
|
0.2950
|
2.99E−07
|
0.2853
|
2.53E−06
|
0.0668
|
5.93E−04
|
|
ILMN_2366041
|
ITM2C
|
2
|
TG
|
− 0.5648
|
6.81E−09
|
− 0.4159
|
3.35E−05
|
− 0.0818
|
6.33E−03
|
|
ILMN_1680453
|
ITM2C
|
2
|
TG
|
− 0.5880
|
5.50E−08
|
− 0.4295
|
0.000124
|
− 0.0818
|
7.05E−03
|
|
ILMN_2352563
|
CLDND1
|
3
|
TG
|
0.3877
|
4.61E−05
|
0.4003
|
6.52E−05
|
0.0656
|
3.53E−02
|
|
ILMN_2079655
|
KLRB1
|
12
|
Insulin
|
0.7694
|
7.01E−09
|
0.6393
|
5.21E−05
|
0.2120
|
5.59E−05
|
|
ILMN_1766657
|
STOM
|
9
|
BMI
|
0.0549
|
3.85E−07
|
NA
|
NA
|
0.0196
|
2.56E−08
|
|
ILMN_1671891
|
PID1
|
2
|
BMI
|
− 0.0425
|
7.23E−09
|
NA
|
NA
|
− 0.0137
|
3.27E−06
|
|
ILMN_2366041
|
ITM2C
|
2
|
BMI
|
− 0.0577
|
1.86E−09
|
NA
|
NA
|
− 0.0123
|
9.53E−05
|
|
ILMN_1773650
|
LRRN3
|
7
|
BMI
|
− 0.0669
|
3.77E−05
|
NA
|
NA
|
− 0.0162
|
1.70E−03
|
|
ILMN_1661599
|
DDIT4
|
10
|
BMI
|
− 0.0658
|
2.75E−07
|
NA
|
NA
|
− 0.0096
|
4.06E−03
|
|
ILMN_2048591
|
LRRN3
|
7
|
BMI
|
− 0.0604
|
1.46E−05
|
NA
|
NA
|
− 0.0086
|
6.95E−03
|
|
ILMN_2377669
|
CD247
|
1
|
BMI
|
− 0.0370
|
5.95E−05
|
NA
|
NA
|
− 0.0058
|
8.01E−03
|
|
ILMN_2109197
|
EPB41L3
|
18
|
BMI
|
− 0.0322
|
0.000112
|
NA
|
NA
|
− 0.0072
|
1.12E−02
|
|
ILMN_2261416
|
CD3D
|
11
|
BMI
|
0.0458
|
6.47E−05
|
NA
|
NA
|
0.0107
|
1.37E−02
|
|
ILMN_2079655
|
KLRB1
|
12
|
BMI
|
0.0669
|
1.63E−05
|
NA
|
NA
|
0.0122
|
2.29E–−02
|
|
ILMN_1761463
|
EFHD2
|
1
|
BMI
|
− 0.0339
|
1.46E−06
|
NA
|
NA
|
− 0.0038
|
4.68E−02
|
- The table shows 21 probes annotated to 19 genes that are significantly associated with cardio-metabolic traits and in eQTM with at least one smoking-related CpG
- Only probes significantly associated in both models and nominally significant (P < 0.05) in the replication are presented in this table
- HDL high-density lipoprotein, TG triglycerides, BMI body mass index, NA not applicable (because of adjusting for BMI)
- Model 1: Adjusted for age, sex, cell count, RNA quality score, and technical covariates. Model 2: Model 1 + BMI and relevant medication
- We did not correct for additional covariates when testing the association for BMI
- P value threshold P < 2.25 × 10–4 (0.05/200)
- P value threshold for replication: HDL, P < 0.01, (0.05/5); TG, P < 3.33 × 10–3 (0.05/15); Insulin, P < 0.03 (0.05/2); BMI, P < 3.13 × 10–3 (0.05/16)
- Genes that are presented underlined passed the replication p value threshold in 687 participants of the KORA study
- aAccording to the by Illumina provided annotation file
