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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Epigenome-wide association study of Alzheimer’s disease replicates 22 differentially methylated positions and 30 differentially methylated regions

Fig. 3

Enrichment of genomic features among the differentially methylated regions (DMRs). The identified DMRs were annotated by HOMER [62]. HOMER first determined the distance of a DMR to the nearest transcription start site (TSS) and assigned the DMR to that gene; it then determined the genomic annotation of the region occupied by the center of the DMR and performed enrichment analysis of genomic features including TTS (transcription termination site), 5′-/3′-untranslated region (UTR), long interspersed nuclear element (LINE), short interspersed nuclear element (SINE), long terminal repeat (LTR), ncRNAs, small nucleolar RNA (snoRNA), small nuclear RNA (snRNA), signal recognition particle RNA (srpRNA), small conditional RNA (scRNA), non-coding RNA (ncRNA), microRNA (miRNA), ribosomal RNA (rRNA), transfer RNA (tRNA), etc.

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Clinical Epigenetics

ISSN: 1868-7083

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