Serious neonatal morbidities are associated with differences in DNA methylation among very preterm infants

Clinical Epigenetics

Table 2 CpG-specific associations between DNAm with a linear increase in composite neonatal morbidity risk score, adjusted for gestational age at birth (weeks), sex, whether the infant was outborn, the proportion of epithelial cells, recruitment site, batch, and PMA (weeks) where appropriate; the beta coefficient represents the average difference in DNA methylation for each increase in the number of morbidities that the infant experienced (BPD, SBI, ROP, or infection); gene annotations verified in UCSC Genome Browser (hg19)

CpG Site	Coef	Std. Err	p value	FDR	Chr	Pos	Gene	Region
cg06343740	0.0111	0.0020	2.91E−08	0.0029	chr22	26878410	HPS4;SRRD	5′UTR;TSS1500;Body
cg07846767	0.0224	0.0038	4.83E−09	0.0011	chr6	167443722	FGFR1OP	Body
cg08303167	0.0265	0.0048	4.50E−08	0.0033	chr6	126953300	6q22.33	–
cg09787236	0.0278	0.0047	3.82E−09	0.0011	chr6	74652865	6q13	–
cg11255857	0.0187	0.0034	4.08E−08	0.0033	chr7	47431773	TNS3	Body
cg12861771	− 0.0137	0.0024	6.96E−09	0.0012	chr15	76442477	TMEM266	Body
cg16636226	0.0254	0.0045	1.93E−08	0.0023	chr3	26669219	LRRC3B	5′UTR
cg20938154	− 0.0081	0.0014	1.86E−08	0.0023	chr19	40597336	ZNF780A	TSS1500
cg24517837	0.0312	0.0053	4.65E−09	0.0011	chr5	167391645	TENM2	Body
cg26838315	0.0423	0.0077	4.64E−08	0.0033	chr10	59559554	10q21.1	–

CpG cytosine-phosphate-guanine site, Coef. estimated difference in DNAm associated with an increase of one in the neonatal morbidity risk score, Std. Err. standard error, FDR false discovery rate, Chr. chromosome, Pos. genomic location (hg19)

ISSN: 1868-7083