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Table 1 Distribution of demographic characteristics, neonatal morbidities and maternal/fetal characteristics of the study population overall and stratified by composite neonatal morbidity risk scores; ANOVA and χ2 tests were used to assess differences in characteristics across the levels of risk scores

From: Serious neonatal morbidities are associated with differences in DNA methylation among very preterm infants

Sample characteristics (N = 532)

Stratified by Risk Score

 

Overall

0 (n = 213)

1 (n = 193)

2 (n = 98)

3 + (n = 28)

p value

BPD (%)

273 (51.3)

0 (0.0)

152 (78.8)

94 (95.9)

27 (96.4)

< 0.001

INF (%)

99 (18.6)

0 (0.0)

24 (12.4)

56 (57.1)

19 (67.9)

< 0.001

SBI (%)

68 (12.8)

0 (0.0)

16 (8.3)

31 (31.6)

21 (75.0)

< 0.001

ROP (%)

34 (6.4)

0 (0.0)

1 (0.5)

15 (15.3)

18 (64.3)

< 0.001

GA (weeks)

27.01 (1.92)

27.95 (1.46)

26.92 (1.83)

25.74 (1.85)

24.91 (1.50)

< 0.001

PMA (weeks)

39.08 (3.29)

36.77 (1.87)

39.77 (2.79)

41.97 (3.31)

41.81 (2.77)

< 0.001

Race and ethnicity (%)

     

0.05

 Hispanic other

68 (12.8)

26 (12.2)

20 (10.4)

19 (19.4)

3 (10.7)

 

 Hispanic white

43 (8.1)

13 (6.1)

16 (8.3)

11 (11.2)

3 (10.7)

 

 Non-Hispanic other

180 (33.8)

76 (35.7)

70 (36.3)

29 (29.6)

5 (17.9)

 

 Non-Hispanic white

234 (44.0)

94 (44.1)

86 (44.6)

39 (39.8)

15 (53.6)

 

 Not reported

7 (1.3)

4 (1.9)

1 (0.5)

0 (0.0)

2 (7.1)

 

Outborn (%)

112 (21.1)

30 (14.1)

34 (17.6)

37 (37.8)

11 (39.3)

< 0.001

Male (%)

297 (55.8)

130 (61.0)

100 (51.8)

54 (55.1)

13 (46.4)

0.201

Maternal age (years)

29.10 (6.39)

29.13 (6.60)

29.49 (6.02)

28.35 (6.77)

28.95 (5.93)

0.556

Education < HS/GED (%)

72 (13.9)

28 (13.7)

21 (11.1)

19 (19.6)

4 (14.8)

0.276

Lowest SES (%)

42 (8.1)

15 (7.4)

15 (7.9)

8 (8.2)

4 (14.8)

0.615

Recruitment site (%)

     

0.001

 WIH

94 (17.7)

30 (14.1)

47 (24.4)

12 (12.2)

5 (17.9)

 

 SHD

100 (18.8)

52 (24.4)

31 (16.1)

12 (12.2)

5 (17.9)

 

 KMC

88 (16.5)

44 (20.7)

25 (13.0)

15 (15.3)

4 (14.3)

 

 CMH

68 (12.8)

16 (7.5)

25 (13.0)

22 (22.4)

5 (17.9)

 

 WFU

113 (21.2)

50 (23.5)

35 (18.1)

21 (21.4)

7 (25.0)

 

 LUB

69 (13.0)

21 (9.9)

30 (15.5)

16 (16.3)

2 (7.1)

 
  1. BPD bronchopulmonary dysplasia, INF neonatal infection, SBI severe brain injury, ROP severe retinopathy of prematurity, GA gestational age, PMA postmenstrual age, HS high school, GED general educational development test, SES socioeconomic status