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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Low-dose DNA demethylating therapy induces reprogramming of diverse cancer-related pathways at the single-cell level

Fig. 3

Difference of demethylated genes between DAC-treated clones. a Comparison of DNA methylation levels between DAC-treated clones. A large fraction of genomic blocks showed different methylation levels between the two clones compared. b Unsupervised hierarchical clustering analysis using DNA methylation profiles of 1039 TSS200CGIs fully methylated in HCT116. Demethylated genes were highly diverse among the DAC-treated clones. c DNA methylation status of genes involved in colon cancer-related pathways. Genes involved in cell cycle regulation, the WNT pathway, the p53 pathway, and the TGF-β pathway were completely demethylated, depending upon clones. d Protein expression levels of DKK3 and SFRP1 in DAC-treated clones. Complete demethylation led to the upregulation of methylation-silenced genes at the protein level in DAC-treated clones

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Clinical Epigenetics

ISSN: 1868-7083

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