Table 5 Two-step epigenetic Mendelian randomization on cocaine and HIV severity (n = 1177)
From: DNA methylation mediates the effect of cocaine use on HIV severity
CpG | Chr | Position | Nearest gene | Step 1: cocaine affecting methylation | Step 2: methylation affecting HIV severity | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Number of IV | Estimate | Standard error | 95% CI | p value†| Number of IV | Estimate | Standard error | 95% CI | p value†| ||||
cg03753191 | 13 | 43566902 | EPSTI1 | 8 | 0.206 | 0.070 | (0.069, 0.343) | 3.27E−03 | 9 | − 10.688 | 2.300 | (− 15.197, − 6.180) | 3.38E−06 |
cg06188083 | 10 | 91093005 | IFIT3 | 8 | 0.269 | 0.109 | (0.056, 0.482) | 1.33E−02 | 4 | − 6.756 | 2.602 | (− 11.856, − 1.656) | 9.42E−03 |
cg26312951 | 21 | 42797847 | MX1 | 8 | 0.286 | 0.137 | (0.018, 0.554) | 3.68E−02 | 12 | − 4.582 | 1.261 | (− 7.053, − 2.111) | 2.79E−04 |
cg22917487 | 3 | 39322103 | CX3CR1 | 8 | 0.090 | 0.045 | (0.001, 0.179) | 4.83E−02 | 7 | − 3.522 | 5.577 | (− 14.453, 7.410) | 5.28E−01 |
cg08122652 | 3 | 122281939 | PARP9 | 8 | 0.259 | 0.141 | (− 0.017, 0.536) | 6.61E−02 | 8 | − 4.517 | 1.558 | (− 7.571, − 1.463) | 3.75E−03 |
cg22930808 | 3 | 122281881 | PARP9 | 8 | 0.245 | 0.164 | (− 0.076, 0.567) | 1.35E−01 | 10 | − 5.245 | 1.135 | (− 7.470, − 3.019) | 3.85E−06 |
cg08818207 | 6 | 32820355 | TAP1 | 8 | 0.092 | 0.071 | (− 0.048, 0.231) | 1.96E−01 | 2 | − 10.287 | 5.519 | (− 21.104, 0.530) | 6.23E−02 |
cg03038262 | 11 | 315262 | IFITM1 | 8 | 0.099 | 0.081 | (− 0.059, 0.257) | 2.20E−01 | 4 | − 9.610 | 3.955 | (− 17.361, − 1.859) | 1.51E−02 |
cg22940798 | 6 | 32805554 | TAP2 | 8 | 0.047 | 0.042 | (− 0.035, 0.128) | 2.62E−01 | 2 | − 28.774 | 9.027 | (− 46.466, − 11.082) | 1.43E−03 |
cg06981309 | 3 | 146260954 | PLSCR1 | 8 | 0.107 | 0.097 | (− 0.083, 0.296) | 2.69E−01 | 4 | 1.502 | 2.983 | (− 4.344, 7.349) | 6.15E−01 |
cg00096307 | 2 | 106761754 | UXS1 | 8 | 0.036 | 0.033 | (− 0.030, 0.101) | 2.84E−01 | 2 | 3.455 | 11.853 | (− 19.776, 26.685) | 7.71E−01 |
cg07839457 | 16 | 57023022 | NLRC5 | 8 | 0.109 | 0.158 | (− 0.200, 0.418) | 4.88E−01 | 7 | − 2.961 | 1.552 | (− 6.004, 0.081) | 5.64E−02 |
cg26396492 | 20 | 19915762 | RIN2 | 8 | 0.014 | 0.031 | (− 0.047, 0.075) | 6.50E−01 | 10 | − 9.992 | 5.226 | (− 20.234, 0.250) | 5.59E−02 |
cg08623256 | 5 | 3858275 |  | 8 | 0.009 | 0.029 | (− 0.048, 0.066) | 7.58E−01 | 1 | 18.246 | 15.315 | (− 11.772, 48.263) | 2.34E−01 |
cg22385827 | 2 | 211036478 | C2orf67 | 8 | 0.025 | 0.125 | (− 0.219, 0.269) | 8.41E−01 | 3 | 1.054 | 1.855 | (− 2.582, 4.689) | 5.70E−01 |