Fig. 4

The blue methylation group is characterized by differential methylation of genes involved in transcriptional and translational regulation. a The Venn diagram shows the distribution of DMPs between the three differentially methylated groups. The top left circle represents DMPs between the blue and yellow groups. The top right circle represents DMPs between blue and pink groups. The bottom circle represents DMPs between the pink and yellow groups. b The heatmap shows the hierarchical clustering of participants using the 19 DMPs that were observed between blue vs yellow and blue vs pink, but not pink vs yellow. The promoters of (c) INTS5, d) KDM2A, (e) UTP14A, (f) XPO1, (g) ZBTB44, and (h) ZNF444 were examined for differential methylation. DNA methylation is reported using M-values as mean ± SEM. All reported DMPs have FDR p value >0.01