Fig. 1

a Output reads from methylation specific targeted sequencing. Bars indicate the output yield in terms of number of reads (millions) for each of the analyzed individuals. Blue bars indicate the total number of reads, while red bars indicate number of reads mapping to the genome. b Percentage of mapped reads on primary (blue) and capture target regions (red) for each sample. c Number of CpGs called in the analyzed samples. Blue bars show identified CpGs and red bars show CpGs with > 10 reads in all samples and a non-zero methylation ratio. d Bisulfite conversion efficiency (> 99.5% recommended; dotted line) for each sample