Table 3 Distribution of DMCs according to chromatin regions of placenta
From: Epigenome-wide DNA methylation profiling of preeclamptic placenta according to severe features
Chromatin regions | Hypomethylated DMCs in PE, compared with the PE with severe features (N = 240) | Hypermethylated DMCs in PE, compared with the PE with severe features (N = 139) | ||
|---|---|---|---|---|
n | % | n | % | |
Active enhancer 1 | 3 | 1.3 | 5 | 3.6 |
Active enhancer 2 | 3 | 1.3 | 5 | 3.6 |
Active TSS | 0 | 0.0 | 5 | 3.6 |
Bivalent enhancer | 8 | 3.3 | 10 | 7.2 |
Bivalent/poised TSS | 6 | 2.5 | 1 | 0.7 |
Flanking TSS | 8 | 3.3 | 9 | 6.5 |
Flanking TSS downstream | 3 | 1.3 | 3 | 2.2 |
Flanking TSS upstream | 3 | 1.3 | 4 | 2.9 |
Genic enhancer1 | 0 | 0.0 | 1 | 0.7 |
Genic enhancer2 | 2 | 0.8 | 1 | 0.7 |
Heterochromatin | 33 | 13.8 | 8 | 5.8 |
Quiescent/low | 51 | 21.3 | 38 | 27.3 |
Repressed Polycomb | 27 | 11.3 | 3 | 2.2 |
Strong transcription | 8 | 3.3 | 2 | 1.4 |
Weak enhancer | 13 | 5.4 | 17 | 12.2 |
Weak repressed Polycomb | 46 | 19.2 | 13 | 9.4 |
Weak transcription | 14 | 5.8 | 10 | 7.2 |
ZNF genes and repeats | 12 | 5.0 | 4 | 2.9 |