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Table 3 Distribution of DMCs according to chromatin regions of placenta

From: Epigenome-wide DNA methylation profiling of preeclamptic placenta according to severe features

Chromatin regions Hypomethylated DMCs in PE, compared with the PE with severe features (N = 240) Hypermethylated DMCs in PE, compared with the PE with severe features (N = 139)
n % n %
Active enhancer 1 3 1.3 5 3.6
Active enhancer 2 3 1.3 5 3.6
Active TSS 0 0.0 5 3.6
Bivalent enhancer 8 3.3 10 7.2
Bivalent/poised TSS 6 2.5 1 0.7
Flanking TSS 8 3.3 9 6.5
Flanking TSS downstream 3 1.3 3 2.2
Flanking TSS upstream 3 1.3 4 2.9
Genic enhancer1 0 0.0 1 0.7
Genic enhancer2 2 0.8 1 0.7
Heterochromatin 33 13.8 8 5.8
Quiescent/low 51 21.3 38 27.3
Repressed Polycomb 27 11.3 3 2.2
Strong transcription 8 3.3 2 1.4
Weak enhancer 13 5.4 17 12.2
Weak repressed Polycomb 46 19.2 13 9.4
Weak transcription 14 5.8 10 7.2
ZNF genes and repeats 12 5.0 4 2.9