- The level of the combined model with IGFBP-1, MMP-9, and H3.1 containing cf-nucleosomes (probability of SSC-ILD) computed at T1 was evaluated in relation to PFT for all patients. Significant negative correlations are observed between the model and FVC (% pred) and TLC (% pred). The negative correlation is still significant and even stronger between the model computed with T1 measurements and TLC (% pred) quantified at T2 (but not with FVC at T2), which means that the model could be a predictor of disease progression for TLC (% pred) at T2
