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Table 2 Levels blood biomarkers

From: A new nucleosomic-based model to identify and diagnose SSc-ILD

Biomarkers T1 (n = 98) T2 (n = 37)
SSc (n = 67) SSc-ILD (n = 31) Sig. SSc (n = 27) SSc-ILD (n = 10) Sig.
Median IQR Median IQR Median IQR Median IQR
MMP-9 820.5 435-1354 1243.4 887-1724 * 1164.9 389-1599 903.14 366-1647  
IGFBP-1 14.96 8.6-25.5 5.74 2.2-14.3 *** 11.04 7.3-24.6 5.6 2.7-33.1  
H3.1 66.4 41-102 82.6 65-146 * 56.2 41-79 77.6 55-172 *
  1. The levels of IGFBP-1, MMP-9, and H3.1 containing cf-nucleosomes (median and IQR) were evaluated at T1 and T2 for SSc and SSC-ILD patients. Significant differences were observed between SSc and SSc-ILD patients for all three biomarkers at T1. At T2, only the level of H3.1 containing cf-nucleosome remained significantly higher in SSc-ILD patients
  2. P values were determined by Mann-Whitney rank-sum test