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Table 2 Levels blood biomarkers

From: A new nucleosomic-based model to identify and diagnose SSc-ILD

Biomarkers

T1 (n = 98)

T2 (n = 37)

SSc (n = 67)

SSc-ILD (n = 31)

Sig.

SSc (n = 27)

SSc-ILD (n = 10)

Sig.

Median

IQR

Median

IQR

Median

IQR

Median

IQR

MMP-9

820.5

435-1354

1243.4

887-1724

*

1164.9

389-1599

903.14

366-1647

 

IGFBP-1

14.96

8.6-25.5

5.74

2.2-14.3

***

11.04

7.3-24.6

5.6

2.7-33.1

 

H3.1

66.4

41-102

82.6

65-146

*

56.2

41-79

77.6

55-172

*

  1. The levels of IGFBP-1, MMP-9, and H3.1 containing cf-nucleosomes (median and IQR) were evaluated at T1 and T2 for SSc and SSC-ILD patients. Significant differences were observed between SSc and SSc-ILD patients for all three biomarkers at T1. At T2, only the level of H3.1 containing cf-nucleosome remained significantly higher in SSc-ILD patients
  2. P values were determined by Mann-Whitney rank-sum test
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Clinical Epigenetics

ISSN: 1868-7083

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