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Table 1 Overview of DNA methylation markers in stool evaluated for detection of different stages of colorectal cancer (CRC) and its precursors

From: Fecal DNA methylation markers for detecting stages of colorectal cancer and its precursors: a systematic review

Gene Chromosome Chen, 2005 [41] Lenhard, 2005 [23] Abbaszadegan, 2007 [42] Itzkowitz, 2008 [39] Wang, 2008 [43] Baek, 2009 [44] Hellebrekers, 2009 [37] Kim, 2009 [24] Nagasaka, 2009 [45] Chang, 2010 [46] Kalimutho, 2011 [33] Tang, 2011 [47] Guo, 2013 [25] Zhang, 2013 [48] He, 2014 [26] Lu, 2014 [49] Wu, 2014 [36] Zhang, 2014 [50] Li, 2015 [27] Xiao, 2015 [32] Kriegshäuser, 2017 [38] Niu, 2017 [51] Oh, 2017 [35] Park, 2017 [34] Yang, 2017 [52] Han, 2019 [28] Liu, 2019 [40] Report frequency Significant resultsa
miR-34a 1                             1 1
ITGA4 2           □↑                  2 2
TLX2 2                            ∆↑ 1 1
MLH1 3       □↑                       1 1
BMP3 4                         □↑     1 1
SFRP2 4          □↑       ∆↑   ∆↑       □↑     10 10
SNCA 4                             2 2
OSMR 5                             1 1
TFPI2 7                         □↑     1 1
GATA4 8                 ∆↑             3 3
SDC2 8                            3 3
CDKN2A 9           □↑                   2 2
MGMT 10       □↑                       1 1
VIM 10      □↑           ∆↑             5 5
miR-34b/c 11                             2 2
WIF-1 12                   ∆↑           2 2
COL4A1 13                            1 1
COL4A2 13                            ∆↑ 1 1
ING1 13                             1 1
SPART 13                             1 1
FBN1 15                             2 2
NDRG4 16                 ∆↑         □↑     4 3
HIC1 17                             1 1
GATA5 20                 ∆↑             2 2
RASSF2 20                             1 1
  1. a Frequency of significant results for association of methylation status of gene with overall CRC risk
  2. Represents markers evaluated only individually
  3. □ Represents markers evaluated only in a panel
  4. ∆ Represents markers evaluated both individually and in a panel
  5. ↑ Represents hypermethylated marker in CRC cases compared to controls
  6. √ Represents no p-value reported or could be calculated