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Table 2 Associations between physical and lifestyle traits, and serum CRP and the DNAm CRP score

From: Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

Lothian Birth Cohort 1936
 CRP DNAm CRP
  β SE P FDR P β SE P FDR P
  BMI 0.27 0.03 3.1 × 10−18 2.1 × 10−17 0.14 0.04 8.1 × 10−5 2.4 × 10−4
  Alcohol − 0.004 0.03 0.26 0.41 0.12 0.03 5.9 × 10−4 0.001
  SIMD − 0.05 0.03 0.14 0.25 − 0.12 0.03 2.7 × 10−4 7.2 × 10−4
  Smoking 0.30 0.07 4.2 × 10−6 1.4 × 10−5 0.54 0.07 2.7 × 10−13 1.5 × 10−12
Generation Scotland
 CRP DNAm—subset with measured CRP DNAm—full dataset
  β SE P FDR P β SE P FDR P β SE P FDR P
  BMI 0.29 0.04 7.2 × 10−11 3.3 × 10−10 0.15 0.06 0.009 0.019 0.19 0.01 8.7 × 10−40 2.4 × 10−38
  Alcohol 0.01 0.07 0.83 0.91 0.19 0.06 0.001 0.003 0.15 0.01 7.1 × 10−25 9.6 × 10−24
  SIMD 0.03 0.05 0.53 0.64 − 0.04 0.06 0.45 0.64 − 0.07 0.01 3.7 × 10−7 1.4 × 10−6
  Smoking 0.26 0.11 0.01 0.03 0.16 0.11 0.17 0.29 0.24 0.03 1.7 × x10−19 1.5 × 10−18
  1. Log odds are presented for smoking. Analysis was run at wave 1 of the Lothian Birth Cohort 1936 (n = 1091). Significant associations are highlighted in bold
  2. SIMD Scottish Index of Multiple Deprivation, BMI body mass index, CRP C-reactive protein, DNAm DNA methylation, SE standard error, FDR false discovery rate