Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

Clinical Epigenetics

Table 2 Associations between physical and lifestyle traits, and serum CRP and the DNAm CRP score

Lothian Birth Cohort 1936
CRP					DNAm CRP
	β	SE	P	FDR P	β		SE			P		FDR P
BMI	0.27	0.03	3.1 × 10⁻¹⁸	2.1 × 10⁻¹⁷	0.14		0.04			8.1 × 10⁻⁵		2.4 × 10⁻⁴
Alcohol	− 0.004	0.03	0.26	0.41	0.12		0.03			5.9 × 10⁻⁴		0.001
SIMD	− 0.05	0.03	0.14	0.25	− 0.12		0.03			2.7 × 10⁻⁴		7.2 × 10⁻⁴
Smoking	0.30	0.07	4.2 × 10⁻⁶	1.4 × 10⁻⁵	0.54		0.07			2.7 × 10⁻¹³		1.5 × 10⁻¹²
Generation Scotland
CRP					DNAm—subset with measured CRP				DNAm—full dataset
	β	SE	P	FDR P	β	SE	P	FDR P	β	SE	P	FDR P
BMI	0.29	0.04	7.2 × 10⁻¹¹	3.3 × 10⁻¹⁰	0.15	0.06	0.009	0.019	0.19	0.01	8.7 × 10⁻⁴⁰	2.4 × 10⁻³⁸
Alcohol	0.01	0.07	0.83	0.91	0.19	0.06	0.001	0.003	0.15	0.01	7.1 × 10⁻²⁵	9.6 × 10⁻²⁴
SIMD	0.03	0.05	0.53	0.64	− 0.04	0.06	0.45	0.64	− 0.07	0.01	3.7 × 10⁻⁷	1.4 × 10⁻⁶
Smoking	0.26	0.11	0.01	0.03	0.16	0.11	0.17	0.29	0.24	0.03	1.7 × x10⁻¹⁹	1.5 × 10⁻¹⁸

Log odds are presented for smoking. Analysis was run at wave 1 of the Lothian Birth Cohort 1936 (n = 1091). Significant associations are highlighted in bold
SIMD Scottish Index of Multiple Deprivation, BMI body mass index, CRP C-reactive protein, DNAm DNA methylation, SE standard error, FDR false discovery rate

ISSN: 1868-7083