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Table 1 The numbers of the patients with eight representative epi-IDs and affected DMRs

From: Assisted reproductive technology represents a possible risk factor for development of epimutation-mediated imprinting disorders for mothers aged ≥ 30 years

epi-IDs Affected DMRs n
Silver-Russell syndrome H19/IGF2:IG-DMR hypomethylation 77
Beckwith-Wiedemann syndrome H19/IGF2:IG-DMR hypermethylation 9
KCNQ1OT1:TSS-DMR hypomethylation 22
Kagami-Ogata syndrome MEG3/DLK1:IG-DMR and MEG3:TSS-DMR hypermethylation 5
Temple syndrome MEG3/DLK1:IG-DMR and MEG3:TSS-DMR hypomethylation 4
Prader-Willi syndrome SNURF:TSS-DMR hypermethylation 4
Angelman syndrome SNURF:TSS-DMR hypomethylation 5
Pseudohypoparathyroidism 1B GNAS A/B:TSS-DMR hypomethylation 8
Transient neonatal diabetes mellitus PLAGL1:alt-TSS-DMR hypomethylation 2
Total   136
  1. epi-IDs epimutation-mediated imprinting disorders, DMRs differentially methylated regions