Assisted reproductive technology represents a possible risk factor for development of epimutation-mediated imprinting disorders for mothers aged ≥ 30 years

Table 1 The numbers of the patients with eight representative epi-IDs and affected DMRs

epi-IDs	Affected DMRs	n
Silver-Russell syndrome	H19/IGF2:IG-DMR hypomethylation	77
Beckwith-Wiedemann syndrome	H19/IGF2:IG-DMR hypermethylation	9
Beckwith-Wiedemann syndrome	KCNQ1OT1:TSS-DMR hypomethylation	22
Kagami-Ogata syndrome	MEG3/DLK1:IG-DMR and MEG3:TSS-DMR hypermethylation	5
Temple syndrome	MEG3/DLK1:IG-DMR and MEG3:TSS-DMR hypomethylation	4
Prader-Willi syndrome	SNURF:TSS-DMR hypermethylation	4
Angelman syndrome	SNURF:TSS-DMR hypomethylation	5
Pseudohypoparathyroidism 1B	GNAS A/B:TSS-DMR hypomethylation	8
Transient neonatal diabetes mellitus	PLAGL1:alt-TSS-DMR hypomethylation	2
Total		136

epi-IDs epimutation-mediated imprinting disorders, DMRs differentially methylated regions

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