Fig. 6

Transcription factors (TFs) annotated from enriched transcription factor binding motifs (TFBMs) in the differentially acetylated regions (DARs). a A Venn diagram shows the overlap of motif-encoded TFs that were linked to TFBMs found to be enriched in DARs. In the graph below are shown the gene set enrichment analysis of genes encoding these TFs with differentially expressed genes between patients and controls. Differentially expressed genes per study are ranked by their fold changes and shown on the x-axis. The running correlation throughout the gene set is shown by the curve (green) and the running enrichment score (ES) is shown in the y-axis. Enrichment score normalized for gene set size (NES) and the false discovery rate (FDR) are shown above each plot. Black bars indicate annotated genes from differentially acetylated regions that are presented among the transcriptome profiles. b A subset of TFs that present the same direction in the acetylation activity and mRNA expression change in remodeled myocardium as compared to the controls