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Table 3 Results of MANCOVA of DNA methylation at OXTR CpG sites between drug-naïve patients with OCD and healthy controls for men and women

From: Reduced DNA methylation of the oxytocin receptor gene is associated with obsessive-compulsive disorder

  Men Women
OCDa (n = 32) HCa (n = 56)   OCDa (n = 13) HCa (n = 52)  
F pb ηp2c F pb ηp2c
   Statistics: Wilks λ = 0.840, F(4, 81) = 3.843, p = 0.007 Statistics: Wilks λ = 0.666, F(4, 58) = 7.285, p < 0.001
OXTR1 (exon2) CpG1 (-959) 41.49 ± 5.66 45.67 ± 4.88 7.642 0.007 0.083 42.75 ± 5.96 47.70 ± 3.89 10.389 < 0.001 0.193
  CpG2 (-934) 46.41 ± 4.73 50.44 ± 4.52 14.633 < 0.001 0.148 48.87 ± 3.72 52.54 ± 3.14 5.908 0.002 0.147
  CpG3 (-924) 57.41 ± 4.45 59.62 ± 3.82 6.044 0.016 0.067 61.49 ± 6.12 60.74 ± 3.75 0.695 0.368 0.013
OXTR2 (exon3) Mean value of CpG1-8 14.32 ± 6.31 13.34 ± 5.66 0.388 0.535 0.005 13.79 ± 4.27 14.14 ± 4.57 0.274 0.599 0.005
  1. MANCOVA demonstrated significant between-group difference after controlling for age and education
  2. MANCOVA multivariate analysis of covariance, OCD obsessive-compulsive disorder, HC healthy control
  3. aMean ± standard deviation of raw data
  4. bStatistical significance was set at p < 0.0125 after Bonferroni correction for 4 CpG sites
  5. cEffect size was calculated using partial eta squared and interpreted according to the rule of Miles and Shevlin (2001)
  6. Medium effect (> 0.06)
  7. Large effect (> 0.14)