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Table 3 Results of MANCOVA of DNA methylation at OXTR CpG sites between drug-naïve patients with OCD and healthy controls for men and women

From: Reduced DNA methylation of the oxytocin receptor gene is associated with obsessive-compulsive disorder

 

Men

Women

OCDa (n = 32)

HCa (n = 56)

 

OCDa (n = 13)

HCa (n = 52)

 

F

pb

ηp2c

F

pb

ηp2c

  

Statistics: Wilks λ = 0.840, F(4, 81) = 3.843, p = 0.007

Statistics: Wilks λ = 0.666, F(4, 58) = 7.285, p < 0.001

OXTR1 (exon2)

CpG1 (-959)

41.49 ± 5.66

45.67 ± 4.88

7.642

0.007

0.083†

42.75 ± 5.96

47.70 ± 3.89

10.389

< 0.001

0.193‡

 

CpG2 (-934)

46.41 ± 4.73

50.44 ± 4.52

14.633

< 0.001

0.148‡

48.87 ± 3.72

52.54 ± 3.14

5.908

0.002

0.147‡

 

CpG3 (-924)

57.41 ± 4.45

59.62 ± 3.82

6.044

0.016

0.067

61.49 ± 6.12

60.74 ± 3.75

0.695

0.368

0.013

OXTR2 (exon3)

Mean value of CpG1-8

14.32 ± 6.31

13.34 ± 5.66

0.388

0.535

0.005

13.79 ± 4.27

14.14 ± 4.57

0.274

0.599

0.005

  1. MANCOVA demonstrated significant between-group difference after controlling for age and education
  2. MANCOVA multivariate analysis of covariance, OCD obsessive-compulsive disorder, HC healthy control
  3. aMean ± standard deviation of raw data
  4. bStatistical significance was set at p < 0.0125 after Bonferroni correction for 4 CpG sites
  5. cEffect size was calculated using partial eta squared and interpreted according to the rule of Miles and Shevlin (2001)
  6. †Medium effect (> 0.06)
  7. ‡Large effect (> 0.14)
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Clinical Epigenetics

ISSN: 1868-7083

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