Skip to main content
Fig. 7 | Clinical Epigenetics

Fig. 7

From: Alternative methylation of intron motifs is associated with cancer-related gene expression in both canine mammary tumor and human breast cancer

Fig. 7

Conservation of intron DMRs and associating RNA expression in the candidate genes between HBC and CMT. Hypermethylated candidate genes, aCDH5 and bLRIG1. Hypomethylated candidate genes, cCDH2 and dADAM19. Human gene structures are line-drawn with intron PAX5 and PAX6 motifs (arrows). Wanderer database provided CG methylation levels in normal (blue line) and cancer (red line). CGs surrounding PAX motifs are labeled in red (hypermethylation) or in blue (hypomethylation). Scatter plot presents anti-correlation between methylation level in selected CG and gene expression; normal: blue, cancer: red. Box plot shows overall gene expression levels of normal (blue) and cancer (red) in TCGA database

Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us