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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Alternative methylation of intron motifs is associated with cancer-related gene expression in both canine mammary tumor and human breast cancer

Fig. 5

PAX motifs are enriched in hyper- and hypomethylated intron DMRs. Consensus motif sequence and sequence frequency of a PAX5 and b PAX6 motif. CGs on the motifs are highlighted with red. Accumulated heatmaps present 5 kb up- and downstream regions of c PAX5 and d PAX6 motifs. Hyper- (orange) and hypo- (blue) methylation. e and f Differential methylation peaks between 11 adjacent normal (green) and 11 cancer (purple) samples visualized with motif loci, DMRs, CGI, and gene structure annotations. p values for each DMR were generated by paired t test. The level of candidate gene expression (log2(FPKM+1) of gCDH5 and LRIG1, and hCDH2 and ADAM19 in adjacent normal (light blue) and cancer (dark blue)

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Clinical Epigenetics

ISSN: 1868-7083

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