DNA methylation for cervical cancer screening: a training set in China

Clinical Epigenetics

Table 3 The diagnostic accuracy of different screening strategies for cervical histology

Histology of cervix	Cytology		hrHPV		EPB41L3 or JAM3		hrHPV+ methylation
Histology of cervix	Negative	ASCUS+	Negative	Positive	Negative	Positive^a	Negative	Positive^a
Inflammation or CIN1 (n = 118)	4	114	30	88	108	10	112	6
CIN2+ (n = 183)	12	171	19	164	51	132	59	124
Sensitivity for CIN2+	93.44%		89.62%		72.13%		67.76%
Specificity for CIN2+	3.39%		25.42%		91.53%		94.92%
Negative predictive value for CIN2+	0.250		0.612		0.679		0.655
Positive predictive value for CIN2+	0.600		0.651		0.930		0.954

ASCUS atypical squamous cells of undetermined significance, CIN2+ lesions of cervical intraepithelial neoplasia (CIN) 2 or more severe, hrHPV high-risk human papilloma virus, N/A not available
^aPositive methylation status indicates calculated values of at least one of the targeted genes below the cutoff values

ISSN: 1868-7083