Table 1 The association between histological findings and methylation analysis with and without hrHPV testing
From: DNA methylation for cervical cancer screening: a training set in China
Histology | PositiveaEPB41L3, n (%) | PositiveaJAM3, n (%) | Positive EPB41L3 or positive JAM3, n (%) | Positive hrHPV, n (%) | Positive hrHPV + methylation, n (%) | |
|---|---|---|---|---|---|---|
Inflammation or LSIL (n = 118) | Inflammation (n = 78) | 4 (5.13) | 7 (8.97) | 8 (10.26) | 55 (70.51) | 5 (9.09) |
CIN1 (n = 40) | 1 (2.50) | 1 (2.50) | 2 (5.00) | 31 (77.50) | 1 (3.23) | |
HSIL (n = 120) | CIN2 (n = 29) | 3 (10.34) | 5 (17.24) | 6 (20.69) | 21 (72.41) | 4 (19.05) |
CIN3 (n = 91) | 56 (61.54) | 64 (70.33) | 65 (71.43) | 83 (91.21) | 61 (73.49) | |
Malignancies (n = 68) | SCC (n = 52) | 51 (98.08) | 51 (98.08) | 51 (98.08) | 49 (94.23) | 49 (94.23) |
Endocervical ADC (n = 11) | 8 (72.73) | 10 (90.91) | 10 (90.91) | 9 (81.82) | 9 (81.82) | |