Fig. 5
From: Prognostic and predictive value of PD-L2 DNA methylation and mRNA expression in melanoma
Progression-free survival in two cohorts of metastasized melanoma patients treated with immune checkpoint blockade in association to PD-L2 methylation and PD-L2 mRNA expression. Kaplan–Meier analysis of progression-free survival in metastasized melanoma patients stratified according to cg07211259 methylation (a) and PD-L2 mRNA expression (b) levels in pre-treatment samples. Patient samples were dichotomized based on optimized cutoffs. Follow-up data was available from N = 129 (methylation cohort) and N = 121 (mRNA expression cohort obtained from Liu et al. [25]) patients, respectively