Fig. 1

Scheme of the choice of SNP–methylation pairs used in the analyses presented here. For each SNP (green circle), we detect all the CpGs within 50 kb and check which of those are in a promoter, gene, or enhancer region. Note that some of the CpGs can be part of more than one region type, while some have no annotation. Next, we summarize the DNAm values of all CpGs within each region and use this single value to create strata and search for gene–methylation (G ×Me) or parent-of-origin–methylation (PoO ×Me) interaction. For each SNP, we perform six analyses at most