Fig. 1

Scatterplots of TREX1 DNA methylation, transcript expression, and measures of SCLC drug sensitivity. a Methylation of the TSS200 region vs log(IC50) of TAK-901. Horizontal scale represents the average methylation beta-value among the probes in the TREX1 TSS200 region, whereas the vertical scale represents the log(IC50) values of TAK-901. b Methylation of the 5′UTR region vs log(IC50) of TAK-901. Horizontal scale represents the average methylation of the TREX1 5′UTR region, and the vertical scale represents the log(IC50) values of TAK-901. c Methylation of the 5′UTR region of TREX1 vs TREX1 expression. Horizontal scale represents the average methylation of the TREX1 5′UTR region, whereas the vertical scale represents the log₂-transformed TREX1 expression measures. dTREX1 expression vs log(IC50) of TAK-901. Horizontal scale represents the log₂-transformed TREX1 expression values, and the vertical scale represents the log(IC50) values of TAK-901. eTREX1 expression vs log(IC50) of R-547. Horizontal scale represents the log₂-transformed TREX1 expression values, and the vertical scale represents the log(IC50) values of R-547. f Methylation of the probe cg27340749 vs log(IC50) of R-547. Horizontal scale represents the average methylation of the cg27340749, which is jointly annotated as being the 5′UTR and first exon of TREX1. The vertical scale represents the log(IC50) values of R-547. ρ, Spearman correlation coefficient. r, Pearson correlation coefficient. The original p values (p_O) are provided for respective Spearman and Pearson correlation analyses