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Table 1 Placental DNA methylation CpG sites associated with birthweight

From: DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases

CpG site

Chr

Position

Gene

Relation to island

Gene group

Coeff (95% CI)

p value

FDR p value

cg10442325

2

48401950

Intergenic

OpenSea

 

0.017 (0.009, 0.024)

2.18E− 08

9.0E− 03

cg00768487

1

26611311

UBXN11

OpenSea

Body

0.020 (0.006, 0.034)

2.44E− 07

2.8E− 02

cg11444072

2

9427798

ASAP2

OpenSea

Body

0.019 (0.005, 0.033)

1.86E− 07

2.8E− 02

cg12866292

17

8079312

TMEM107

N_Shore

Body

0.010 (0.004, 0.016)

2.72E− 07

2.8E− 02

cg15936066

8

42356637

SLC20A2

OpenSea

5′UTR

0.027 (0.012, 0.041)

4.56E− 07

3.1E− 02

cg19367232

2

68478649

PPP3R1

N_Shore

Body

− 0.007 (− 0.010, − 0.004)

4.09E− 07

3.1E− 02

cg06155341

11

66048759

CNIH2

N_Shore

Body

0.009 (0.003, 0.014)

7.74E− 07

4.0E− 02

cg15017278

16

127449

MPG

Island

5′UTR

0.012 (0.002, 0.022)

7.75E− 07

4.0E− 02

cg03110787

19

6217641

MLLT1

S_Shelf

Body

0.012 (0.004, 0.019)

1.65E− 06

4.5E− 02

cg03599729

2

200820225

C2orf60

Island

Body

− 0.003 (− 0.004, − 0.001)

1.55E− 06

4.5E− 02

cg07538190

8

22458182

C8orf58

S_Shore

Body

0.011 (0.003, 0.019)

1.33E− 06

4.5E− 02

cg08973382

2

74728623

LBX2

N_Shore

Body

0.007 (0.002, 0.012)

1.25E− 06

4.5E− 02

cg09467508

3

137486265

Intergenic

N_Shore

 

0.028 (0.013, 0.044)

1.36E− 06

4.5E− 02

cg10806146

8

42356871

SLC20A2

OpenSea

5′UTR

0.041 (0.020, 0.062)

1.13E− 06

4.5E− 02

cg24450112

21

44103949

PDE9A

N_Shore

Body

− 0.026 (− 0.039, − 0.013)

1.60E− 06

4.5E− 02

  1. Position: base pair position based on hg19 human reference genome
  2. Relation to island: Shore = 0–2 kb from island, Shelf = 2–4 kb from island, N = upstream (5′) of CpG island, S = downstream (3′) of CpG island
  3. Coeff % change in methylation beta value per 10 g increase in birthweight, FDR false discovery rate