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Table 1 Placental DNA methylation CpG sites associated with birthweight

From: DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases

CpG site Chr Position Gene Relation to island Gene group Coeff (95% CI) p value FDR p value
cg10442325 2 48401950 Intergenic OpenSea   0.017 (0.009, 0.024) 2.18E− 08 9.0E− 03
cg00768487 1 26611311 UBXN11 OpenSea Body 0.020 (0.006, 0.034) 2.44E− 07 2.8E− 02
cg11444072 2 9427798 ASAP2 OpenSea Body 0.019 (0.005, 0.033) 1.86E− 07 2.8E− 02
cg12866292 17 8079312 TMEM107 N_Shore Body 0.010 (0.004, 0.016) 2.72E− 07 2.8E− 02
cg15936066 8 42356637 SLC20A2 OpenSea 5′UTR 0.027 (0.012, 0.041) 4.56E− 07 3.1E− 02
cg19367232 2 68478649 PPP3R1 N_Shore Body − 0.007 (− 0.010, − 0.004) 4.09E− 07 3.1E− 02
cg06155341 11 66048759 CNIH2 N_Shore Body 0.009 (0.003, 0.014) 7.74E− 07 4.0E− 02
cg15017278 16 127449 MPG Island 5′UTR 0.012 (0.002, 0.022) 7.75E− 07 4.0E− 02
cg03110787 19 6217641 MLLT1 S_Shelf Body 0.012 (0.004, 0.019) 1.65E− 06 4.5E− 02
cg03599729 2 200820225 C2orf60 Island Body − 0.003 (− 0.004, − 0.001) 1.55E− 06 4.5E− 02
cg07538190 8 22458182 C8orf58 S_Shore Body 0.011 (0.003, 0.019) 1.33E− 06 4.5E− 02
cg08973382 2 74728623 LBX2 N_Shore Body 0.007 (0.002, 0.012) 1.25E− 06 4.5E− 02
cg09467508 3 137486265 Intergenic N_Shore   0.028 (0.013, 0.044) 1.36E− 06 4.5E− 02
cg10806146 8 42356871 SLC20A2 OpenSea 5′UTR 0.041 (0.020, 0.062) 1.13E− 06 4.5E− 02
cg24450112 21 44103949 PDE9A N_Shore Body − 0.026 (− 0.039, − 0.013) 1.60E− 06 4.5E− 02
  1. Position: base pair position based on hg19 human reference genome
  2. Relation to island: Shore = 0–2 kb from island, Shelf = 2–4 kb from island, N = upstream (5′) of CpG island, S = downstream (3′) of CpG island
  3. Coeff % change in methylation beta value per 10 g increase in birthweight, FDR false discovery rate