Table 3 Mendelian randomization (MR) analysis results, assessing epigenetic mediation between alcohol consumption and ~ 3-year survival at the KHDC3L gene (chromosome 6:74072255-74072376). Inverse-variance weighted adjusted for genetic correlation between mQTLs (IVW), MR Egger and Wald ratio results are each reported as hazard ratios with 95% confidence intervals
Region (gene) | MR method | SNPs | HR | 95% CI | P |
|---|---|---|---|---|---|
All DMR CpGs | |||||
 Chr6:74072255-74072376 (KHDC3L) | IVW | 4 | 1.17 | 0.70 to 1.97 | 0.55 |
 Chr6:74072255-74072376 (KHDC3L) | MR Egger | 4 | 0.89 | 0.27 to 2.98 | 0.85 |
Sentinel CpG only | |||||
 cg19146112 (KHDC3L) | Wald ratio | 1 | 1.17 | 0.54 to 2.53 | 0.68 |