Table 3 Replication of differential methylation across datasets (using Fernandez et al. Leukocyte data)
Comparison | Gene | Discovery CpG | Discovery P-value | Replication CpG locus | Replication P-value |
|---|---|---|---|---|---|
AD vs CN | ADCYAP1 | cg16288125 | 3.02 × 10-5 | chr18:905,549-905,550 | 3.78E-09 |
EPHB3 | cg22462726 | 2.57 × 10-6 | chr3:184,561,230-184,561,231 | 1.78E-05 | |
GDF10 | cg00414835 | 2.5 × 10-5 | chr10:47,300,094-47,300,095 | 7.89E-04 | |
PARP1 | cg27113848 | 2.74 × 10-5 | chr1:226,408,700-226,408,701 | 1.25E-01 | |
MCI vs AD | DAB2IP | cg20416296 | 8.69 × 10-6 | chr9:121,698,699-121,698,700 | 4.49E-01 |
MET | cg04432493 | 8.6 × 10-5 | chr7:116,672,738-116,672,739 | 7.05E-03 | |
APOC1 | cg07773593 | 6.06 × 10-5 | chr19:44,914,258-44,914,259 | 9.97E-03 | |
ITGB1 | cg05376034 | 6.42 × 10-5 | chr10:32,958,721-32,958,722 | 6.20E-02 | |
MCI vs CN | SOX1 | cg07911664 | 9.5 × 10-6 | chr13:112,066,581-112,066,582 | 1.12E-01 |
WNT1 | cg22376688 | 1.56 × 10-5 | chr12:48,972,583-48,972,584 | 3.90E-06 | |
DAPK1 | cg10240127 | 3.1 × 10-5 | chr9:87,497,927-87,497,928 | 8.85E-04 |