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Table 2 Clinical performance of HPV 16 methylation and E6 oncoprotein in triaging HPV 16 positive women for the detection of CIN3+

From: Risk stratification of HPV 16 DNA methylation combined with E6 oncoprotein in cervical cancer screening: a 10-year prospective cohort study

Triage strategiesReferral rate (%, 95% CI)Sensitivity (%, 95% CI)Specificity (%, 95% CI)PPV (%, 95% CI)NPV (%, 95% CI)Youden index (%, 95% CI)AUC (%, 95% CI)
Methyl panel A39.2 (27.0, 52.9)85.7 (60.1, 96.0)78.4 (62.8, 88.6)60.0 (38.7, 78.1)93.5 (79.3, 98.2)64.1 (52.2, 76.0)0.82 (0.69, 0.91)
Methyl panel B19.6 (11.2, 32.5)57.1 (32.6, 78.6)94.6 (82.3, 98.5)80.0 (49.0, 94.3)85.4 (71.6, 93.1)51.7 (39.3, 64.1)0.76 (0.62, 0.87)
E6 oncoprotein25.5 (15.6, 38.9)57.1 (32.6, 78.6)86.5 (72.0, 94.1)61.5 (35.5, 82.3)84.2 (69.6, 92.6)43.6 (31.3, 55.9)0.72 (0.58, 0.84)
Methyl panel A+E6 oncoprotein45.1 (32.3, 58.6)92.9 (68.5, 98.7)73.0 (57.0, 84.6)56.5 (36.8, 74.4)96.4 (82.3, 99.4)65.9 (54.1, 77.7)0.83 (0.70, 0.92)
Methyl panel B+E6 oncoprotein35.3 (23.6, 49.0)78.6 (52.4, 92.4)81.1 (65.8, 90.5)61.1 (38.6, 79.7)90.9 (76.4, 96.9)59.7 (47.5, 71.9)0.80 (0.66, 0.90)
Cytology66.7 (53.0, 78.0)92.9 (68.5, 98.7)43.2 (28.7, 59.1)38.2 (23.9, 55.0)94.1 (73.0, 99.0)36.1 (24.1, 48.1)0.68 (0.54, 0.80)
Viral load35.3 (23.6, 49.0)57.1 (32.6, 78.6)73.0 (57.0, 84.6)44.4 (24.6, 66.3)81.8 (65.1, 91.4)30.1 (18.7, 41.5)0.65 (0.50, 0.78)
VIA33.3 (22.0, 47.0)35.7 (16.4, 61.2)67.6 (51.5, 80.4)29.4 (13.3, 53.1)73.5 (56.9, 85.4)3.3 (− 1.1, 7.7)0.52 (0.37, 0.66)
  1. HPV human papillomavirus, CIN3+ cervical intraepithelial neoplasia grade 3 or worse, Methyl, methylation, VIA visual inspection with acetic acid, PPV positive predictive value, NPV negative predictive value, CI confidence interval, AUC area under the curve