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Table 7 Association of phenotypic and DNAm-based predictors of smoking, alcohol drinking, BMI and education with mortality

From: Epigenetic prediction of complex traits and mortality in a cohort of individuals with oropharyngeal cancer

  Minimally adjusteda    Fully adjustedb  
ExposureNHRllulP value NcHRllulP value
Self-reported phenotype
 Ever vs never smoker3643.291.756.182.22 × 10−4 3642.211.144.300.019
 Hazardous to harmful drinker vs not3641.621.062.490.027 3641.340.862.090.202
 Higher education vs school education3640.810.541.220.320 3640.870.571.310.503
 BMI2480.930.870.990.028 2480.980.921.060.664
DNAm score
Smoking
  McCartney LASSO (233 CpG sites)3641.531.241.887.89 × 10-5 3641.200.941.520.144
  Trejo Bayesian (59 CpG sites)3641.701.372.111.49 × 10-6 3641.260.931.720.140
AHRR (cg05575921)3640.590.480.741.72 × 10-6 3640.790.581.070.125
Joehanes (FDR) (18,760 CpG sites)3641.701.342.151.27 × 10−5 3641.350.991.840.056
  Joehanes (Bonferroni) (2623 CpG sites)3641.671.362.057.57 × 10−7 3641.381.041.830.025
  Zhang (4 CpG sites)3641.481.161.881.48 × 10−3 3641.281.021.600.036
Alcohol
  Liu (5 CpG sites)3641.321.101.572.50 × 10−3 3641.190.971.470.094
  Liu (23 CpG sites)3641.261.041.520.019 3641.100.891.360.357
  Liu (78 CpG sites)3641.251.071.455.02 × 10−3 3641.200.991.450.067
  Liu (144 CpG sites)3641.241.071.445.31 × 10−3 3641.211.001.460.052
  McCartney LASSO (450 CpG sites)3641.281.031.600.024 3641.050.791.410.723
BMI
  Trejo Bayesian (144 CpG sites)3640.780.630.970.024 2480.770.561.080.132
  McCartney LASSO (1109 CpG Sites)3640.850.681.060.146 2480.770.571.040.093
Education
  McCartney LASSO (373 CpG sites)3640.760.610.960.021 3640.870.681.120.270
  1. N number, HR hazard ratio, ll lower confidence interval, ul upper confidence interval. aSelf-reported phenotypes adjusted for age and gender; epigenetic scores adjusted for age, gender, cell counts and batch effects. bPhenotypes additionally adjusted for clinical variables (TNM stage, HPV status and comorbidity), and a combination of smoking, alcohol intake, education and BMI, as appropriate to the model; risk scores additionally adjusted for clinical variables, the corresponding phenotype predicted by the score of interest and the remaining self-reported phenotypes (excluding BMI). cSample numbers vary due to missing BMI data