|  | Minimally adjusteda |  |  |  |  | Fully adjustedb |  |  | ||
---|---|---|---|---|---|---|---|---|---|---|---|
Exposure | N | HR | ll | ul | P value | Â | Nc | HR | ll | ul | P value |
Self-reported phenotype | |||||||||||
 Ever vs never smoker | 364 | 3.29 | 1.75 | 6.18 | 2.22 × 10−4 |  | 364 | 2.21 | 1.14 | 4.30 | 0.019 |
 Hazardous to harmful drinker vs not | 364 | 1.62 | 1.06 | 2.49 | 0.027 |  | 364 | 1.34 | 0.86 | 2.09 | 0.202 |
 Higher education vs school education | 364 | 0.81 | 0.54 | 1.22 | 0.320 |  | 364 | 0.87 | 0.57 | 1.31 | 0.503 |
 BMI | 248 | 0.93 | 0.87 | 0.99 | 0.028 |  | 248 | 0.98 | 0.92 | 1.06 | 0.664 |
DNAm score | |||||||||||
Smoking | |||||||||||
  McCartney LASSO (233 CpG sites) | 364 | 1.53 | 1.24 | 1.88 | 7.89 × 10-5 |  | 364 | 1.20 | 0.94 | 1.52 | 0.144 |
  Trejo Bayesian (59 CpG sites) | 364 | 1.70 | 1.37 | 2.11 | 1.49 × 10-6 |  | 364 | 1.26 | 0.93 | 1.72 | 0.140 |
AHRR (cg05575921) | 364 | 0.59 | 0.48 | 0.74 | 1.72 × 10-6 |  | 364 | 0.79 | 0.58 | 1.07 | 0.125 |
Joehanes (FDR) (18,760 CpG sites) | 364 | 1.70 | 1.34 | 2.15 | 1.27 × 10−5 |  | 364 | 1.35 | 0.99 | 1.84 | 0.056 |
  Joehanes (Bonferroni) (2623 CpG sites) | 364 | 1.67 | 1.36 | 2.05 | 7.57 × 10−7 |  | 364 | 1.38 | 1.04 | 1.83 | 0.025 |
  Zhang (4 CpG sites) | 364 | 1.48 | 1.16 | 1.88 | 1.48 × 10−3 |  | 364 | 1.28 | 1.02 | 1.60 | 0.036 |
Alcohol | |||||||||||
  Liu (5 CpG sites) | 364 | 1.32 | 1.10 | 1.57 | 2.50 × 10−3 |  | 364 | 1.19 | 0.97 | 1.47 | 0.094 |
  Liu (23 CpG sites) | 364 | 1.26 | 1.04 | 1.52 | 0.019 |  | 364 | 1.10 | 0.89 | 1.36 | 0.357 |
  Liu (78 CpG sites) | 364 | 1.25 | 1.07 | 1.45 | 5.02 × 10−3 |  | 364 | 1.20 | 0.99 | 1.45 | 0.067 |
  Liu (144 CpG sites) | 364 | 1.24 | 1.07 | 1.44 | 5.31 × 10−3 |  | 364 | 1.21 | 1.00 | 1.46 | 0.052 |
  McCartney LASSO (450 CpG sites) | 364 | 1.28 | 1.03 | 1.60 | 0.024 |  | 364 | 1.05 | 0.79 | 1.41 | 0.723 |
BMI | |||||||||||
  Trejo Bayesian (144 CpG sites) | 364 | 0.78 | 0.63 | 0.97 | 0.024 |  | 248 | 0.77 | 0.56 | 1.08 | 0.132 |
  McCartney LASSO (1109 CpG Sites) | 364 | 0.85 | 0.68 | 1.06 | 0.146 |  | 248 | 0.77 | 0.57 | 1.04 | 0.093 |
Education | |||||||||||
  McCartney LASSO (373 CpG sites) | 364 | 0.76 | 0.61 | 0.96 | 0.021 |  | 364 | 0.87 | 0.68 | 1.12 | 0.270 |